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首页> 外文期刊>Journal of Clinical Microbiology >Phylogenetic Analysis of Invasive Serotype 1 Pneumococcus in South Africa, 1989 to 2013
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Phylogenetic Analysis of Invasive Serotype 1 Pneumococcus in South Africa, 1989 to 2013

机译：1989年至2013年南非侵袭性1型肺炎球菌的系统发育分析

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Serotype 1 is an important cause of invasive pneumococcal disease in South Africa and has declined following the introduction of the 13-valent pneumococcal conjugate vaccine in 2011. We genetically characterized 912 invasive serotype 1 isolates from 1989 to 2013. Simpson's diversity index (D) and recombination ratios were calculated. Factors associated with sequence types (STs) were assessed. Clonal complex 217 represented 96% (872/912) of the sampled isolates. Following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), ST diversity increased in children <5 years (D, 0.39 to 0.63, P = 0.002) and individuals >14 years (D, 0.35 to 0.54, P < 0.001): ST-217 declined proportionately in children <5 years (153/203 [75%] versus 21/37 [57%], P = 0.027) and individuals >14 years (242/305 [79%] versus 96/148 [65%], P = 0.001), whereas ST-9067 increased (4/684 [0.6%] versus 24/228 [11%], P < 0.001). Three subclades were identified within ST-217: ST-217C1 (353/382 [92%]), ST-217C2 (15/382 [4%]), and ST-217C3 (14/382 [4%]). ST-217C2, ST-217C3, and single-locus variant (SLV) ST-8314 (20/912 [2%]) were associated with nonsusceptibility to chloramphenicol, tetracycline, and co-trimoxazole. ST-8314 (20/912 [2%]) was also associated with increased nonsusceptibility to penicillin (P < 0.001). ST-217C3 and newly reported ST-9067 had higher recombination ratios than those of ST-217C1 (4.344 versus 0.091, P < 0.001; and 0.086 versus 0.013, P < 0.001, respectively). Increases in genetic diversity were noted post-PCV13, and lineages associated with antimicrobial nonsusceptibility were identified.
机译：血清型1是南非侵袭性肺炎球菌疾病的重要原因，并且在2011年引入13价肺炎球菌结合疫苗后有所下降。我们对1989年至2013年间的912侵袭性血清型1分离株进行了遗传学鉴定。Simpson的多样性指数（D）和计算重组率。评估与序列类型（ST）相关的因素。克隆复合物217代表了采样分离物中的96％（872/912）。引入13价肺炎球菌结合疫苗（PCV13）后，<5岁儿童（D，0.39至0.63， P = 0.002）和> 14岁儿童（D，0.35）的ST多样性增加降至0.54， P <0.001）：<5岁儿童的ST-217比例下降（153/203 [75％]对21/37 [57％]， P = 0.027）和大于14岁的个人（242/305 [79％]对96/148 [65％]， P = 0.001），而ST-9067有所增加（4/684 [0.6％]）对比24/228 [11％]， P <0.001）。在ST-217中识别出三个子小节：ST-217 C1 （353/382 [92％]），ST-217 C2 （15/382 [4％]） ，和ST-217 C3 （14/382 [4％]）。 ST-217 C2 ，ST-217 C3 和单基因座变异体（SLV）ST-8314（20/912 [2％]）与氯霉素的不敏感性相关，四环素和复方新诺明。 ST-8314（20/912 [2％]）也与对青霉素的不敏感性增加有关（ P <0.001）。 ST-217 C3 和新近报道的ST-9067的重组率比ST-217 C1 高（4.344对0.091， P <0.001 ;分别为0.086和0.013， P <0.001）。在PCV13之后发现了遗传多样性的增加，并鉴定了与抗菌药不敏感性相关的血统。

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