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首页> 外文期刊>Journal of Clinical Microbiology >Spoligotype Profile of Mycobacterium tuberculosis Complex Strains from HIV-Positive and -Negative Patients in Nigeria: a Comparative Analysis
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Spoligotype Profile of Mycobacterium tuberculosis Complex Strains from HIV-Positive and -Negative Patients in Nigeria: a Comparative Analysis

机译：尼日利亚HIV阳性和阴性患者结核分枝杆菌复杂菌株的Spoligotype概况：比较分析

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We ran a comparative analysis of all patients for whom a positive culture of Mycobacterium tuberculosis complex was available between April 2004 and October 2005 and whose HIV serology results were known, with spoligotyping results (n = 163) split into 49 HIV-positive patients and 114 HIV-negative patients. Spoligotype international type 373 (SIT373) (T1 lineage), which was highly prevalent among the HIV+ patients, was totally absent from the HIV? population, suggesting that we had a specific clone affecting nearly 1/3 of all HIV-tuberculosis (TB)-coinfected patients. Among the LAM10-CAM sublineage strains, we had only a single strain of SIT403 among HIV? patients (0.88%), as opposed to 12.25% of the HIV+ population (χ2 = 10.77; P < 0.01), indicating a strong association between the strain and the HIV+ population. The LAM10-CAM lineage spoligotype SIT61 was prevalent among the 2 subsets (37.72% in HIV? versus 12.24% in HIV+ populations), though, with a significant difference between the 2 groups (χ2 = 10.53; P < 0.01). However, there was no significant difference for SIT53 (T1 lineage) in the 2 subsets: 6.14 versus 8.2% (χ2 = 0.22; P > 0.05). A total of 7/49, or 14.3%, other SITs among HIV+ patients were not found among the HIV? patients. When added to the most prevalent SIT among HIV+ patients (SIT373; n = 16), 23/49, or 47%, isolates among HIV-TB-coinfected patients were unique. We conclude that further studies should be carried out to investigate the evolution of these genotypes and others in the emergence of multidrug resistance and control of tuberculosis in Nigeria.
机译：我们对所有患者进行了比较分析，这些患者在2004年4月至2005年10月之间可获得结核分枝杆菌复合物的阳性培养物，并且其HIV血清学结果已知，并带有血脂分型结果（ n = 163）分为49位HIV阳性患者和114位HIV阴性患者。 HIV + 患者中高度流行的Spoligotype国际型373（SIT373）（T1谱系）在HIV ？人群中完全不存在，这表明我们有一个特定的克隆感染了将近1/3的HIV-结核病合并感染患者。在LAM10-CAM亚系菌株中，HIV ？患者中只有一个SIT403菌株（0.88％），而HIV + 人群中只有12.25％（ χ 2 = 10.77; P <0.01），表明该菌株与HIV + 人群之间有很强的联系。 LAM10-CAM谱系spoligotype SIT61在两个亚组中普遍存在（HIV ？人群中为37.72％，HIV + 人群中为12.24％），但是2组（χ 2 = 10.53; P <0.01）。但是，SIT53（T1谱系）在两个子集中没有显着差异：6.14比8.2％（χ 2 = 0.22; P 患者中未发现总共7/49，或14.3％的其他SIT。当添加到HIV + 患者中最普遍的SIT（SIT373; n = 16），23/49或47％时，感染HIV-TB的患者中分离出的细菌是独特。我们得出结论，在尼日利亚多药耐药性和结核病控制的出现中，应进行进一步的研究以调查这些基因型和其他基因型的进化。

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