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首页> 外文期刊>Journal of Clinical Microbiology >Emergence and Continuous Evolution of Genotype 1E Rubella Viruses in China
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Emergence and Continuous Evolution of Genotype 1E Rubella Viruses in China

机译：基因型1E风疹病毒在中国的出现和持续进化

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In China, rubella vaccination was introduced into the national immunization program in 2008, and a rubella epidemic occurred in the same year. In order to know whether changes in the genotypic distribution of rubella viruses have occurred in the postvaccination era, we investigate in detail the epidemiological profile of rubella in China and estimate the evolutionary rate, molecular clock phylogeny, and demographic history of the predominant rubella virus genotypes circulating in China using Bayesian Markov chain Monte Carlo phylodynamic analyses. 1E was found to be the predominant rubella virus genotype since its initial isolation in China in 2001, and no genotypic shift has occurred since then. The results suggest that the global 1E genotype may have diverged in 1995 and that it has evolved at a mutation rate of 1.65 × 10?3 per site per year. The Chinese 1E rubella virus isolates were grouped into either cluster 1 or cluster 2, which likely originated in 1997 and 2006, respectively. Cluster 1 viruses were found in all provinces examined in this study and had a mutation rate of 1.90 × 10?3 per site per year. The effective number of infections remained constant until 2007, and along with the introduction of rubella vaccine into the national immunization program, although the circulation of cluster 1 viruses has not been interrupted, some viral lineages have disappeared, and the epidemic started a decline that led to a decrease in the effective population size. Cluster 2 viruses were found only in Hainan Province, likely because of importation.
机译：在中国，2008年将风疹疫苗接种纳入国家免疫规划，同年发生风疹流行。为了了解在疫苗接种后风疹病毒的基因型分布是否发生了变化，我们详细调查了中国风疹的流行病学概况，并估计了风疹病毒主要基因型的进化率，分子钟系统发育和人口历史贝叶斯马尔可夫链蒙特卡洛系统动力学分析在中国的环流。自从2001年在中国首次分离出1E以来，它一直是风疹病毒的主要基因型，此后没有发生基因型改变。结果表明，全球1E基因型可能在1995年发生了分化，并且以每个站点每年1.65×10 的突变率进化。中国的1E风疹病毒分离株分为1类或2类，它们可能分别起源于1997年和2006年。在这项研究中检查的所有省份都发现了簇1病毒，其每个站点每年的突变率为1.90×10 ？3 。直到2007年，有效感染次数一直保持不变，并且随着风疹疫苗被引入国家免疫计划，尽管第1类病毒的传播并未中断，但一些病毒谱系已经消失，流行病开始减少，导致减少有效人口规模。第2类病毒仅在海南省发现，可能是由于进口。

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