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首页> 外文期刊>Journal of Clinical Microbiology >Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov.
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Subcutaneous Phaeohyphomycotic Nodule Due to Phialemoniopsis hongkongensis sp. nov.

机译：拟南芥（Phialemoniopsis hongkongensis sp。）引起的皮下疏藻性结节。十一月

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Phialemoniopsis species are ubiquitous dematiaceous molds associated with a wide variety of superficial and systemic infections in human. In this study, we isolated a mold from the forearm nodule biopsy specimen from a patient with underlying liver cirrhosis, ankylosing spondylosis, and tuberculosis. He was treated with itraconazole, but unfortunately, he succumbed as a result of disseminated tuberculosis with multiorgan failure. The histology results of the skin biopsy showed necrotizing granulomas in which numerous fungal elements were found. On Sabouraud dextrose agar, the fungal isolate grew as white-to-cream and smooth-to-velvety colonies. Microscopically, oval-to-cylindrical conidia were observed from abundant adelophialides, which possessed barely visible parallel collarettes but no basal septa. The azole drugs voriconazole, itraconazole, and posaconazole, as well as amphotericin B, showed high activities against this fungus. Internal transcribed spacer, 28S nuclear ribosomal DNA (nrDNA), and β-actin and β-tubulin gene sequencing showed that this fungus is most closely related to but distinct from Phialemonium curvata. Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) and hierarchical cluster analysis showed that the MALDI-TOF MS spectrum of this fungus is most closely related to that of Phialemonium pluriloculosa. We propose a new species, Phialemoniopsis hongkongensis sp. nov., to describe this fungus.
机译：疟原虫属物种是普遍存在的皮肤病霉菌，与人类的各种浅表和全身感染有关。在本研究中，我们从患有基础肝硬化，强直性脊柱病和肺结核的患者的前臂结节活检标本中分离出了霉菌。他曾接受伊曲康唑治疗，但不幸的是，他因弥散性结核病和多器官衰竭而屈服。皮肤活检的组织学结果显示坏死性肉芽肿，其中发现了许多真菌成分。在Sabouraud葡萄糖琼脂上，真菌分离物以白色至奶油状和光滑至柔软的菌落生长。在显微镜下，从丰富的自生植物中观察到椭圆形至圆柱形的分生孢子，其几乎没有可见的平行项圈，但没有基底隔。唑类药物伏立康唑，伊曲康唑和泊沙康唑以及两性霉素B对这种真菌表现出高活性。内部转录间隔区，28S核糖体DNA（nrDNA）以及β-肌动蛋白和β-微管蛋白基因测序表明，这种真菌与Ph虫最密切相关，但与之不同。基质辅助激光解吸电离-飞行时间质谱（MALDI-TOF MS）和层次聚类分析表明，该真菌的MALDI-TOF MS谱图与毛鳞Ph最密切相关。我们提出了一个新种，Phialemoniopsis hongkongensis sp。十一月，描述这种真菌。

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