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首页> 外文期刊>Journal of Clinical Microbiology >Is Follow-Up Testing with the FilmArray Gastrointestinal Multiplex PCR Panel Necessary?
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Is Follow-Up Testing with the FilmArray Gastrointestinal Multiplex PCR Panel Necessary?

机译：FilmArray胃肠道多重PCR面板需要进行后续测试吗？

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The FilmArray gastrointestinal (GI) panel (BioFire Diagnostics, Salt Lake City, UT) is a simple, sample-to-answer, on-demand, multiplex, nucleic acid amplification test for syndromic diagnosis of infectious gastroenteritis. The aim of this study was to measure the yield of follow-up testing with FilmArray GI panel within 4 weeks of an initial test. Consecutive adult and pediatric patients tested at an academic institution between August 2015 and June 2016 were included in this study. Of 145 follow-up tests in 106 unique patients with an initial negative result, 134 (92.4%) tests and 98 (92.5%) patients remained negative upon follow-up testing. Excluding targets that are not reported at this institution (Clostridium difficile, enteroaggregative Escherichia coli, enteropathogenic E. coli, and enterotoxigenic E. coli), 137 (94.5%) follow-up tests and 101 (95.3%) patients remained negative. Weekly conversion rates were not significantly different across the 4-week follow-up interval. No epidemiological or clinical factors were significantly associated with a negative to positive conversion. Of 80 follow-up tests in patients with an initial positive result, 43 (53.8%) remained positive for the same target, 34 (42.5%) were negative, and 3 were positive for a different target (3.8%). Follow-up testing with FilmArray GI panel within 4 weeks of a negative result rarely changed the initial result, and the follow-up test reverted to negative less than half the time after an initial positive result. In the absence of clinical or epidemiological evidence for a new infection, follow-up testing should be limited and FilmArray GI panel should not be used as a test of cure.
机译：FilmArray胃肠道（GI）面板（BioFire Diagnostics，犹他州盐湖城）是一种简单的，按需回答，按需，多重核酸扩增试验，用于感染性胃肠炎的综合诊断。这项研究的目的是在初始测试的4周内测量FilmArray GI面板的后续测试的合格率。这项研究包括2015年8月至2016年6月在某学术机构接受检测的连续成人和儿童患者。在106位独特的患者中进行了145项随访测试，但最初结果均为阴性，其中134项（92.4％）测试和98项（92.5％）患者在随访测试中均保持阴性。排除该机构未报告的靶标（艰难梭菌，肠聚合性大肠杆菌，肠致病性大肠杆菌和产肠毒素的大肠杆菌）之后，有137例（94.5％）随访测试和101例（95.3％）阴性。在4周的随访间隔中，每周转化率没有显着差异。没有流行病学或临床因素与负向正向转化率显着相关。在最初结果为阳性的患者中进行的80次随访测试中，对于同一目标，有43例（53.8％）保持阳性，对于同一目标，有34例（42.5％）阴性，对于其他目标，有3例阳性（3.8％）。 FilmArray GI面板在阴性结果后的4周内进行的后续测试很少会改变初始结果，并且在初始阳性结果后不到一半的时间内，后续测试就恢复为阴性。在没有新感染的临床或流行病学证据的情况下，应限制随访测试，并且不应将FilmArray GI面板用作治愈测试。

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