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首页> 外文期刊>Journal of Clinical Microbiology >Systematic Serological Testing for Hepatitis E Virus in Kidney Transplant Recipients
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Systematic Serological Testing for Hepatitis E Virus in Kidney Transplant Recipients

机译：肾移植受者中戊型肝炎病毒的系统血清学检测

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Hepatitis E virus (HEV) genotype 3 is endemic in Europe and hyperendemic in southern France. Recent reports of a high prevalence of HEV RNA in blood donations and in culinary specialties from this geographical area confirmed the endemicity of HEV and sources of viral transmission in this geographical area. HEV causes acute and chronic hepatitis in solid organ transplant recipients. Since March 2012, we have implemented systematic HEV serological testing in our cohort of kidney transplant recipients (KTRs) in Marseille in southeastern France. The aim of our study was to assess HEV exposure in this cohort between March 2012 and May 2014. During these 27 months, we found that 39% of the patients who underwent kidney transplantation had an anti-HEV IgG response using a sensitive microplate enzyme immunoassay. This seroprevalence was approximately 43% at both 1 and 8 years after, using the same assay. In addition, systematic HEV serological testing detected 6 cases of HEV infection among 578 KTRs (1%) during the 27 months of the study, with 5 at an acute stage and 1 at a chronic stage. In conclusion, continuous HEV monitoring in this population is useful for better understanding the epidemiology of HEV in France, because these patients are a well-monitored population. Moreover, HEV monitoring in KTRs is clinically relevant because HEV represents a clinical threat in these patients. Nevertheless, HEV serological testing may be more fruitful for identifying HEV infections when performed in cases of biological liver abnormalities than when performed systematically.
机译：戊型肝炎病毒（HEV）基因型3在欧洲流行，在法国南部流行。最近有关该地区献血和烹饪专业中HEV RNA流行的报道证实了该地区的HEV流行性和病毒传播来源。 HEV在实体器官移植受者中引起急性和慢性肝炎。自2012年3月以来，我们已在法国东南部马赛的肾移植受者（KTR）队列中实施了系统性HEV血清学检测。我们研究的目的是评估该队列在2012年3月至2014年5月之间的戊型肝炎病毒暴露。在这27个月中，我们发现使用敏感的微孔板酶免疫测定法，有39％接受肾脏移植的患者具有抗HEV IgG反应。使用相同的方法，在1年和8年后，该血清阳性率约为43％。此外，在研究的27个月中，系统性HEV血清学检测在578个KTR中检测到6例HEV感染（1％），其中5例处于急性期，1例处于慢性期。总之，对该人群进行持续的HEV监测有助于更好地了解法国HEV的流行病学，因为这些患者是受到良好监测的人群。此外，在KTR中进行HEV监测具有临床意义，因为HEV对这些患者构成临床威胁。尽管如此，在生物学肝异常情况下进行HEV血清学检测可能比在系统上进行筛查更为有效。

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