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首页> 外文期刊>Journal of Clinical Microbiology >Impact of Revised Cefepime CLSI Breakpoints on Escherichia coli and Klebsiella pneumoniae Susceptibility and Potential Impact If Applied to Pseudomonas aeruginosa
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Impact of Revised Cefepime CLSI Breakpoints on Escherichia coli and Klebsiella pneumoniae Susceptibility and Potential Impact If Applied to Pseudomonas aeruginosa

机译：修订后的头孢吡肟CLSI断裂点对大肠杆菌和肺炎克雷伯菌的易感性及其对铜绿假单胞菌的潜在影响

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The CLSI reduced the cefepime Enterobacteriaceae susceptibility breakpoint and introduced the susceptible-dose-dependent (S-DD) category. In this study, MICs were determined for a Gram-negative collection to assess the impact of this change. For Enterobacteriaceae, this resulted in <2% reduction in susceptibility, with 1% being S-DD. If applied to Pseudomonas aeruginosa, the % susceptibility (%S) dropped from 77% to 43%, with 34% being S-DD. The new breakpoints did little to the Enterobacteriaceae %S, but for P. aeruginosa, a profound reduction was seen in %S. The recognition of a S-DD response to cefepime should alert clinicians to the possible need for higher doses.
机译：CLSI降低了头孢吡肟肠杆菌科的敏感性断点，并引入了敏感剂量依赖性（S-DD）类别。在这项研究中，确定MIC为革兰氏阴性菌，以评估这一变化的影响。对于肠杆菌科，这导致药敏性降低<2％，其中S-DD为1％。如果应用于铜绿假单胞菌，则药敏度（％S）从77％降至43％，其中S-DD为34％。新的断点对肠杆菌科％S的影响很小，但是对于铜绿假单胞菌，％S的下降很大。对头孢吡肟的S-DD反应的认识应提醒临床医生可能需要更大剂量。

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