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Population and Functional Genomics of Neisseria Revealed with Gene-by-Gene Approaches

机译:逐基因研究揭示了奈瑟菌的种群和功能基因组学

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Rapid low-cost whole-genome sequencing (WGS) is revolutionizing microbiology; however, complementary advances in accessible, reproducible, and rapid analysis techniques are required to realize the potential of these data. Here, investigations of the genus Neisseria illustrated the gene-by-gene conceptual approach to the organization and analysis of WGS data. Using the gene and its link to phenotype as a starting point, the BIGSdb database, which powers the PubMLST databases, enables the assembly of large open-access collections of annotated genomes that provide insight into the evolution of the Neisseria, the epidemiology of meningococcal and gonococcal disease, and mechanisms of Neisseria pathogenicity.
机译:快速低成本的全基因组测序(WGS)正在彻底改变微生物学;但是,要获得这些数据的潜力,就需要在可访问,可复制和快速的分析技术方面取得互补的进步。在这里,对奈瑟氏球菌属的研究说明了WGS数据的组织和分析的逐个基因概念方法。利用该基因及其与表型的联系作为起点,为PubMLST数据库提供支持的BIGSdb数据库能够对注释基因组的大型开放获取集合进行组装,从而提供对奈瑟氏球菌的进化,脑膜炎球菌和脑膜炎的流行病学的洞察力。淋球菌病和奈瑟菌的致病性机制。

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