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首页> 外文期刊>Journal of Clinical Microbiology >Female Epidemiology of Transcription-Mediated Amplification-Based Trichomonas vaginalis Detection in a Metropolitan Setting with a High Prevalence of Sexually Transmitted Infection
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Female Epidemiology of Transcription-Mediated Amplification-Based Trichomonas vaginalis Detection in a Metropolitan Setting with a High Prevalence of Sexually Transmitted Infection

机译：转录介导的基于扩增的阴道滴虫在大城市环境中的性传播感染流行率很高的女性流行病学

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Recent literature has reported increased accuracy of Trichomonas vaginalis transcription-mediated amplification (TMA)-based analyte-specific reagent (ASR) testing in female populations. A retrospective investigation assessed 7,277 female first-void urine, cervical, or vaginal specimens submitted from a high-prevalence sexually transmitted infection (STI) community to characterize prevalence of disease etiologies. The most common STI phenotype reflected detection of solely T. vaginalis (54.2% of all health care encounters that resulted in STI detection). In females with detectable T. vaginalis, codetection of Chlamydia trachomatis and Neisseria gonorrhoeae occurred in 7.8% and 2.7% of health care encounters, respectively. The mean age of women with detectable T. vaginalis (30.6) was significantly higher than those for women with C. trachomatis or N. gonorrhoeae (22.3 and 21.6, respectively; P < 0.0001). T. vaginalis was the predominant sexually transmitted agent in women over the age of 20 (P < 0.0002). C. trachomatis was the most commonly detected agent in females under the age of 21, particularly from cervical specimens. However, first-void urine detection rates for T. vaginalis and C. trachomatis within this age demographic demonstrated no difference (P = 0.92). While overall and cervical specimen-derived detection of T. vaginalis within African American majority geographical locales outweighed that within majority Caucasian geographical regions (P ≤ 0.004), this difference was not noted with first-void urine screening (P = 0.54). Health care professionals can consider TMA-based T. vaginalis screening for a wide age range of patients; incorporation of first-void urine specimens into screening algorithms can potentiate novel insight into the epidemiology of trichomoniasis.
机译：最近的文献报道了女性人群中阴道毛滴虫转录介导的扩增（TMA）为基础的分析物特异性试剂（ASR）检测的准确性提高。一项回顾性研究评估了从高流行性传播感染（STI）社区提交的7,277例女性初次排尿，宫颈或阴道标本，以表征疾病病因的流行。最常见的性传播感染表型反映出仅检测到阴道锥虫（所有导致性传播感染检测的医疗事件中占54.2％）。在可检出阴道T.的女性中，沙眼衣原体和淋病奈瑟菌的共检测分别发生在7.8％和2.7％的卫生保健中。可检出阴道弯曲杆菌的女性平均年龄（30.6）显着高于沙眼衣原体或淋病奈瑟氏球菌女性的平均年龄（分别为22.3和21.6; P <0.0001）。阴道锥虫是20岁以上女性的主要性传播媒介（ P <0.0002）。沙眼衣原体是21岁以下女性中最常见的病原体，尤其是宫颈标本。但是，在这个年龄段的人群中，阴道毛滴虫和沙眼衣原体的第一空尿检出率没有差异（ P = 0.92）。尽管在非洲裔美国人占多数的地理区域内，总体和子宫颈标本来源的阴道毛滴虫的检测结果超过了白种人的大部分地理区域（ P ≤0.004），但初次尿液筛查并未发现这种差异（ P = 0.54）。卫生保健专业人员可以考虑对年龄广泛的患者进行基于TMA的阴道T.筛查;将初次排尿的尿液样本纳入筛查算法可以增强对滴虫病流行病学的新颖见解。

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