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首页> 外文期刊>Journal of Clinical Microbiology >Persistence, Replacement, and Rapid Clonal Expansion of Meningococcal Carriage Isolates in a 2008 University Student Cohort
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Persistence, Replacement, and Rapid Clonal Expansion of Meningococcal Carriage Isolates in a 2008 University Student Cohort

机译：在2008年大学生队列中脑膜炎球菌支架分离株的持久性，替代性和快速克隆扩增

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A study of meningococcal carriage dynamics was performed with a cohort of 190 first-year students recruited from six residential halls at Nottingham University, United Kingdom. Pharyngeal swabs were obtained on four occasions between November 2008 and May 2009. Direct plating and culture on selective media were succeeded by identification and characterization of meningococci using PCR-based methodologies. Three serogroup Y clones and one serogroup 29E clone were highly prevalent in particular residential halls in November 2008, which is indicative of rapid clonal expansion since the start of the academic year. Persistent carriage of the same meningococcal strain for at least 5 to 6 months was observed in 45% of carriers, with infrequent evidence of antigenic variation in PorA. Sequential carriage of heterologous meningococcal strains occurred in 36% of carriers and involved strains with different capsules and antigenic variants of PorA and FetA in 83% of the cases. These clonal replacement strains also exhibited frequent differences in the presence and antigenic structures of two other surface proteins, NadA and HmbR. This study highlights the low level of antigenic variation associated with persistent carriage but, conversely, the importance of alterations in the repertoire of antigenic variants for sequential carriage of meningococcal strains. Rapid clonal expansion of potentially pathogenic strains in residential halls has implications for the implementation of public health interventions in university populations.
机译：对来自英国诺丁汉大学六个宿舍楼的190名一年级学生的队列进行了脑膜炎球菌运动的研究。在2008年11月至2009年5月之间四次获得咽拭子。使用基于PCR的方法鉴定和鉴定脑膜炎球菌成功地在选择性培养基上进行了直接铺板和培养。在2008年11月的特定住宅大厅中，三个血清群Y克隆和一个血清群29E克隆高度流行，这表明自本学年开始以来，克隆的迅速扩张。在45％的携带者中观察到同一脑膜炎球菌菌株持续运输至少5至6个月，但很少有PorA抗原性变异的证据。异源脑膜炎球菌菌株的顺序运输发生在36％的携带者中，其中83％的病例涉及具有不同荚膜以及PorA和FetA抗原变体的菌株。这些克隆替代菌株在两种其他表面蛋白（NadA和HmbR）的存在和抗原结构上也表现出频繁的差异。这项研究强调了与持续运输相关的抗原变异水平低，但是相反，对于脑膜炎球菌菌株的后续运输而言，抗原变异库中改变的重要性。宿舍大厅中潜在致病菌株的快速克隆扩展对在大学人群中实施公共卫生干预措施具有影响。

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