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首页> 外文期刊>Journal of Clinical Microbiology >Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains
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Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains

机译：459型克隆序列驱动加拿大加拿大曼尼托巴省和萨斯喀彻温省血清型IV B组链球菌成年侵袭性疾病的发生。

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Serotype IV group B Streptococcus (GBS) is emerging in Canada and the United States with rates as high as 5% of the total burden of adult invasive GBS disease. To understand this emergence, we studied the population structure and assessed the antimicrobial susceptibility of serotype IV isolates causing adult invasive infection in Manitoba and Saskatchewan, Canada, between 2010 and 2014. Whole-genome sequencing was used to determine multilocus sequence typing information and identify genes encoding antimicrobial resistance in 85 invasive serotype IV GBS strains. Antimicrobial susceptibility testing was performed by standard methods. Strain divergence was assessed using genome-wide single-nucleotide polymorphism analysis. Serotype IV strains were responsible for 16.9% of adult invasive GBS infections in Manitoba and Saskatchewan during the period. The majority of serotype IV isolates (89%) were clonally related, tetracycline-, erythromycin-, and clindamycin-resistant sequence type 459 (ST459) strains that possessed genes tetM and ermTR. Genome comparisons between ST459 and serotype V ST1 GBS identified several areas of recombination in an overall similar genomic background. Serotype IV ST459 GBS strains are expanding and causing a substantial percentage of adult invasive GBS disease. This emergence may be linked to the acquisition of resistance to tetracycline, macrolides, and lincosamides.
机译：在加拿大和美国，IV型血清型B组链球菌（GBS）的发病率高达成人侵袭性GBS疾病总负担的5％。为了了解这种情况，我们研究了种群结构并评估了2010年至2014年间在加拿大曼尼托巴和萨斯喀彻温省引起成人侵袭性感染的IV型血清型分离株的抗菌敏感性。全基因组测序用于确定多基因座序列类型信息并鉴定基因编码85种侵袭性IV型血清GBS菌株的抗药性。抗菌药敏试验通过标准方法进行。使用全基因组范围的单核苷酸多态性分析评估菌株的差异。在此期间，在曼尼托巴省和萨斯喀彻温省，IV型血清毒株占成人侵入性GBS感染的16.9％。大多数IV型血清分离株（89％）是克隆相关的，具有四环素，红霉素和克林霉素抗性序列类型459（ST459）菌株，这些菌株具有基因 tetM 和 ermTR 。 ST459和血清型V ST1 GBS之间的基因组比较确定了总体相似的基因组背景中的几个重组区域。 IV型ST459 GBS血清型正在扩大，并导致相当大比例的成人侵袭性GBS疾病。这种出现可能与获得对四环素，大环内酯类和林可酰胺的抗性有关。

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