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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Autonomic Nervous System Changesin Chronic Obstructive PulmonaryDisease (Copd) Patients
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Autonomic Nervous System Changesin Chronic Obstructive PulmonaryDisease (Copd) Patients

机译：慢性阻塞性肺疾病（Copd）患者的自主神经系统变化

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Introduction: In the patho-physiology of chronic obstructive pulmonary disease (COPD), changes in the autonomic control of the cardiopulmonary functions are important. The quantification of the para-sympathetic and the sympathetic activity may be useful in treating COPD patients. Aims And Objectives: To observe the changes in the autonomic activity in COPD patients. Material And Methods: The present study was conducted on 90 (male) COPD patients and 30 controls. The para-sympathetic activity tests i.e. the heart rate variation with deep respiration, the valsalva manoeuver, the standing to lying ratio and postural changes (30:15) and the sympathetic activity tests i.e. orthostasis, the cold pressor test (CPT) and the blood pressure response to a sustained hand grip were conducted. An FEV1 which was >80% was the criteria for the healthy control subjects. Results: The heart rate variation to the para-sympathetic stimuli was less in the COPD patients as compared to that in the healthy subjects. The fall in systolic blood pressure (SBP) in response to standing was lesser while the rise in diastolic blood pressure in response to a sustained hand grip was higher in the COPD patients. A significant rise in the SBP in response to CPT was observed. Conclusion: The cardiac para-sympathetic activity was significantly reduced in COPD, while there was sympathoexcitation.
机译：简介：在慢性阻塞性肺疾病（COPD）的病理生理中，心肺功能自主控制的变化很重要。副交感神经和交感神经活性的量化可能对治疗COPD患者有用。目的和目的：观察COPD患者自主神经活动的变化。材料和方法：本研究针对90名（男性）COPD患者和30名对照进行。副交感神经活动测试，即深呼吸的心率变化，瓣膜动作，站立与躺卧的比例和姿势变化（30:15），交感神经活动测试，例如直立性，冷压力测试（CPT）和血液对持续的握力进行压力响应。 FEV1> 80％是健康对照组的标准。结果：与健康受试者相比，COPD患者对副交感神经刺激的心率变化较小。在COPD患者中，站立时收缩压（SBP）的下降较小，而持续握持时舒张压的升高较高。观察到响应CPT的SBP明显升高。结论：COPD时心脏副交感神经活动明显降低，同时有交感神经兴奋。

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