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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Prospective Study of Prognostic Factors for Recurrence in Early Oral Tongue Cancer
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A Prospective Study of Prognostic Factors for Recurrence in Early Oral Tongue Cancer

机译：早期口腔舌癌复发预后因素的前瞻性研究

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Background: Tongue cancer is one of the common cancers in head and neck region. Cervical node metastasis is the strongest poor prognostic factor. Other prognostic factors were also said to be of significance. Our aim was to find out the significant prognostic factors of tumor aggressiveness in Indian perspective.Material and Methods: Sixty cases of early cancer of oral tongue with clinically non palpable neck nodes were managed by upfront surgery. Surgeries performed for the primary tumor were ?wide excision? or ?hemiglossectomy? along with neck dissection. Patients were then given post-operative radiotherapy according to standard guidelines. They were analyzed using a detailed proforma. Three patients were lost to follow-up rest all patients were followed.Results: Recurrence was seen in 11 out of 60 patients (18.3%), in an average follow-up period of about 28 months. Among those who recurred, one patient had both nodal and local recurrence, 2 patients had nodal only (regional) recurrence and rest 8 patients had local recurrence. The prognostic factors that significantly affected the recurrence were endo-phytic disease, depth of invasion, lymphatic invasion, muscle invasion, healthy margin and adjuvant radiotherapy.Conclusion: The risk factors for recurrence in early lesions of oral tongue are - Cervical nodal metastasis, Lymphatic permeation, Depth of disease - 6 mm or more, poorly differentiated tumor, Endophytic (infiltrative) disease, Young age at presentation and Muscle invasion. In early tongue lesions, that are node negative, selective node dissection (SND) including level 1, 2, 3 and 4, is a viable option for neck to decrease the morbidity of MND.
机译：背景：舌癌是头颈部常见的癌症之一。颈淋巴结转移是最差的预后因素。据说其他预后因素也很重要。我们的目的是从印度的角度了解肿瘤侵袭性的重要预后因素。材料与方法：60例早期舌癌，临床上无法触及的颈部淋巴结癌，由前期手术治疗。原发肿瘤的手术是“广泛切除”。或“半结肠切除术”？连同颈部解剖。然后根据标准指南对患者进行术后放疗。他们使用详细的形式进行了分析。结果：3名患者失去了随访休息，所有患者均得到随访。结果：60例患者中有11例复发（18.3％），平均随访期为28个月。在复发者中，1例既有淋巴结又有局部复发，2例仅有淋巴结（区域性）复发，其余8例有局部复发。影响复发的预后因素包括内生植物疾病，浸润深度，淋巴管浸润，肌肉浸润，健康边缘和辅助放疗。结论：口腔早期病变复发的危险因素为-宫颈淋巴结转移，淋巴管炎渗透，疾病深度-6毫米或以上，低分化肿瘤，内生性（浸润性）疾病，出现时的年轻年龄和肌肉侵犯。在结节阴性的早期舌部病变中，包括1、2、3和4级的选择性结节清扫术（SND）是颈部降低MND发病率的可行选择。

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