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Meningitis Due to Cryptococcus gattii in an Immunocompetent Patient

机译:免疫功能正常的患者因加蒂隐球菌引起的脑膜炎

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The incidence of cryptococcal infection is high in developing countries such as India. Cryptococcus gattii, formerly known as Cryptococcus neoformans var gattii, is an encapsulated yeast that causes disease in both immunocompetent and immunosupressed individuals. The organism enters via respiratory tract and causes a spectrum of illness ranging from asymptomatic infection to severe illness, including pneumonia and disseminated infection involving multiple sites, including the central nervous system, eyes and skin. Cryptococcal meningitis is generally considered as rare in immunocompetent patients; therefore, specific treatment is not implemented until the organism is identified or a cryptococcal antigen is detected. We describe the case of a 30-years-old man without prior medical history who presented with meningitis and was treated successfully. This case illustrates the importance of considering infectious causes such as C.gattii in the differential diagnosis of meningitis, regardless of the patient?s immune status.
机译:在印度等发展中国家,隐球菌感染的发生率很高。加氏隐球菌(Cryptococcus gattii),以前称为新隐隐球菌(Cryptococcus neoformans var gattii),是一种封装的酵母,可导致有免疫能力的人和免疫受压的个体患病。该生物体通过呼吸道进入,并引起一系列疾病,从无症状感染到严重疾病,包括肺炎和涉及多个部位的传播感染,包括中枢神经系统,眼睛和皮肤。隐球菌性脑膜炎通常被认为在免疫功能正常的患者中很少见。因此,直到鉴定出该生物或检测到隐球菌抗原后才实施特异性治疗。我们描述了一个30岁无既往病史的男子的病例,该男子曾患有脑膜炎并得到了成功的治疗。该病例说明了在鉴别脑膜炎时,无论患者的免疫状况如何,都必须考虑感染加因氏菌(C. gattii)等因素。

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