...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Changing Trends in ResistancePattern of Methicillin Resistant Staphylococcus aureus
【24h】

Changing Trends in ResistancePattern of Methicillin Resistant Staphylococcus aureus

机译：耐甲氧西林金黄色葡萄球菌耐药模式的变化趋势

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Methicillin resistance in Staphylococcus aureus is associated with multidrug resistance, an aggressive course, increased mortality and morbidity in both community and health care facilities. Monitoring of newly emerging and prevalent Methicillin Resistant Staphylococcus aureus (MRSA) strains for their resistance patterns to conventional as well as novel drugs, are essential for infection control.Aims: To study the changing trends in resistance patterns of MRSA at our hospital.Settings and Design: This cross sectional study was carried out in a 750 bed tertiary care hospital in south India.Material and Methods: One hundred and two clinical isolates of MRSA which were obtained in 2004-2011 were identified by using oxacillin, cefoxitin disc diffusion test and oxacillin screening agar test. Antibiotic susceptibility test was done for commonly used non beta lactam anti-Staphylococcal drugs, as well as for anti-MRSA drugs like vancomycin, linezolid, mupirocin and rifampicin. Minimum inhibitory concentration (MIC) of vancomycin was determined by using Vancomycin HiComb strip (Himedia, Mumbai, India).Statistical Analysis which was done: Chi-square test and proportions were used to compare the two groups.Results: MRSA isolates showed high resistance to co-trimoxazole (82.3%), ciprofloxacin (76.4%), gentamicin (64.7%) and tetracycline (49%) as compared to other drugs. High prevalence of ciprofloxacin resistance was detected, particularly among outpatients. Multi resistant MRSA with a = 3 non-beta lactam agent resistance was 79%. All MRSA isolates were sensitive to vancomycin, linezolid, mupirocin and rifampicin. MRSA had displayed increase in resistance to most antibiotics except tetracycline in recent years.Conclusions: Taking into consideration the prevalence of multidrug resistance in MRSA, resistance patterns should be evaluated periodically and antibiotic therapy should be guided by susceptibility testing.
机译：背景：金黄色葡萄球菌对甲氧西林的耐药性与多重耐药性，侵袭性病程，社区和医疗机构的死亡率和发病率增加有关。监测新出现和流行的耐甲氧西林金黄色葡萄球菌（MRSA）菌株对常规药物和新药的耐药模式对于控制感染至关重要。目的：研究我院MRSA耐药模式的变化趋势。设计：这项横断面研究是在印度南部一家拥有750张床位的三级护理医院中进行的。材料与方法：使用奥沙西林，头孢西丁盘扩散试验和药敏试验鉴定了2004年至2011年获得的102株MRSA临床分离株。奥沙西林筛选琼脂试验。对常用的非β-内酰胺抗葡萄球菌药物以及万古霉素，利奈唑胺，莫匹罗星和利福平等抗MRSA药物进行了药敏试验。使用万古霉素HiComb试纸条（印度孟买，Himedia）测定万古霉素的最低抑菌浓度（MIC）。进行统计分析：卡方检验和比例进行比较。结果：MRSA分离株显示出高耐药性与其他药物相比，共复莫唑（82.3％），环丙沙星（76.4％），庆大霉素（64.7％）和四环素（49％）。环丙沙星耐药性高发，特别是在门诊患者中。具有= 3个非β内酰胺剂耐药性的多重耐药MRSA为79％。所有MRSA分离株均对万古霉素，利奈唑胺，莫匹罗星和利福平敏感。结论：考虑到MRSA中多药耐药的发生率，应定期评估耐药模式，并通过药敏试验指导抗生素治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号