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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours
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Immunohistochemical expression of Type IV Collagen and Autocrine Motility Factor Receptor in Odontogenic Tumours

机译：IV型胶原蛋白和自分泌运动因子受体在牙源性肿瘤中的免疫组织化学表达

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Background: Autocrine motility factor receptor (AMFR) is a tumour motility stimulating protein secreted by tumour cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. It has been known to play a role in progression of neoplastic lesions. Basement membranes are specialized extracellular matrices that serve as structural barriers as well as substrates for cellular interactions. The network of type IV collagen is thought to define the scaffold integrating other components such as laminins and perlecan into highly organized supramolecular architecture. The aim of this study was to determine and evaluate the immunohistochemical expression of Type IV Collagen and Autocrine motility factor receptor in odontogenic lesions.Materials and Methods: Immunohistochemical expression of Type IV Collagen and Autocrine motility factor receptor was evaluated in 31 odontogenic lesions, including unicystic ameloblastoma, multicystic ameloblastoma, keratocystic odontogenic tumour and ameloblastic carcinoma. Normal follicular tissue formed the control.Results: Maximum expression for Type IV Collagen was seen in multicystic ameloblastoma and minimum expression in keratocystic odontogenic tumour. The maximum expression of AMFR was seen in ameloblastic carcinoma and minimum expression in multicystic ameloblastoma.Conclusion: The results of this study suggested an association of loss of expression of type IV Collagen with progression of lesion. AMFR expression was found to be associated with the aggressive potential of tumours.
机译：背景：自分泌运动因子受体（AMFR）是肿瘤细胞分泌的一种肿瘤运动刺激蛋白。该基因编码的蛋白质是糖基化的跨膜蛋白质和自分泌运动因子的受体。已知在肿瘤性病变的进展中起作用。基底膜是专门的细胞外基质，可作为结构屏障以及细胞相互作用的底物。据认为，IV型胶原蛋白网络定义了将其他成分（如层粘连蛋白和Perlecan）整合到高度组织化的超分子体系结构中的支架。本研究旨在确定和评估牙源性病变中IV型胶原蛋白和自分泌运动因子受体的免疫组织化学表达。材料与方法：评估31种牙源性病变（包括单囊性）中IV型胶原蛋白和自分泌运动因子受体的免疫组织化学表达。成釉细胞瘤，多囊性成釉细胞瘤，角化囊性牙源性肿瘤和成釉细胞癌。结果：多囊性成釉细胞瘤中IV型胶原蛋白的最大表达，角膜囊性成牙本质肿瘤中的表达最小。结论：AMFR在釉母细胞癌中表达最高，在多囊性成釉细胞瘤中表达最低。结论：本研究结果提示IV型胶原蛋白表达的丧失与病变的进展有关。发现AMFR表达与肿瘤的侵袭潜能相关。

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