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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Malnutrition Inflammation Complex Syndrome-The Micsing Factor in the Perio-Chronic Kidney Disease Interlink
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The Malnutrition Inflammation Complex Syndrome-The Micsing Factor in the Perio-Chronic Kidney Disease Interlink

机译：营养不良性炎症综合症-慢性肾肾脏疾病中的糖化因子

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The patients who undergo Maintenance Haemodialysis (MHD) have a high prevalence of Protein-Energy Malnutrition (PEM) and inflammation. Because these two conditions often occur concomitantly in the MHD patients, they have been referred to together as the Malnutrition-Inflammation Complex Syndrome (MICS) or Malnutrition-inflammation atherosclerosis, to underscore the atherosclerotic complications of this entity. MICS is also reported to correlate with a poor outcome, including a decreased quality of life, refractory anaemia and significantly greater rates of hospitalization and mortality in the MHD patients .Indeed, MICS may be the major cause of the paradoxical exposure-outcome association, which is also known as reverse epidemiology of the cardiovascular disease risk factors in the maintenance dialysis patients. Periodontitis is a chronic inflammatory disease of the supporting tissues from the dentition, which results from the infection of and the interaction of selected bacterial species with the components of the host response in disease-susceptible individuals as the haemodialysis (HD) patients. Only in recent years, did an emerging evidence link the dental infection, especially periodontitis, to an increased risk of atherosclerosis and thrombosis. In the HD patients, studies have been showing a positive link between periodontal disease and systemic inflammation on correlation between the levels of CRP and immunoglobulin G of Porphyromonas gingivalis. Recent researches have confirmed that the periodontal health is poor in haemodialysis patients and that it correlates with the markers of malnutrition and inflammation.
机译：进行维持性血液透析（MHD）的患者普遍存在蛋白质能量营养不良（PEM）和炎症。由于这两种情况通常在MHD患者中同时发生，因此它们被共同称为营养不良-炎症综合症（MICS）或营养不良-炎症性动脉粥样硬化，以强调该实体的动脉粥样硬化并发症。据报道，MICS与不良预后相关，包括MHD患者生活质量下降，难治性贫血以及住院和死亡率显着增加。事实上，MICS可能是导致自相矛盾的暴露-结果关联的主要原因。在维持性透析患者中​​，心血管疾病的危险因素也被称为逆流行病学。牙周炎是来自牙列的支持组织的慢性炎性疾病，其是由易感染血液病（HD）的易感染个体中选定细菌种类的感染以及宿主反应成分的相互作用引起的。仅在最近几年，才出现新的证据将牙齿感染，尤其是牙周炎与动脉粥样硬化和血栓形成的风险增加联系起来。在HD患者中，研究表明牙周疾病与全身性炎症之间存在正相关关系，这与牙龈卟啉单胞菌的CRP水平和免疫球蛋白G之间的相关性有关。最近的研究证实，血液透析患者的牙周健康状况较差，并且与营养不良和炎症的标志物相关。

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