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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms
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The Microbiological Profiles of Infected Prosthetic Implants with an Emphasis on the Organisms which Form Biofilms

机译：感染假体植入物的微生物学特征，重点是形成生物膜的生物

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Background:In spite of the decreasing incidence of orthopaedic device related infections to 1%, nowadays, device-related infections still remain a diagnostic, therapeutic and cost -related problem.Aims and Objective:To record the common causative organisms and the contributing risk factors for orthopaedic device-related infections in a tertiary care teaching hospital. Methods:In a prospective study, fifty patients who underwent orthopaedic device implantation from Jan 2009 ? June 2010 were enrolled; among them, 42 patients were complicated with infections. The demography, microbiological data, treatment and the outcome of each patient were recorded.Statistical Analysis: The data was analyzed in terms of frequency and percentage. Results:Of the 50 samples, 42(84%) were culture positive, while 8(16%) were cultures negative. The femur was the most commonly affected bone in both males (median age?37.1yrs) and females (median age?41.3 yrs). Staphylococcus aureus was the organism which was most commonly isolated and which caused biofilms, followed by non-fermenting, gram negative bacilli and Klebsiella spp. We reported the first case till date in the literature of Candida kruseiPJI, to the best of our knowledge. No anaerobes were isolated. Tissue trauma, open fractures, post-operative surgical site infections and Diabetes mellitus were found to be the important risk factors. The biofilm forming organisms were commonly associated with polymicrobial infections and even an aggressive antibiotic therapy was often inadequate to eliminate the infections. A conservative surgical treatment was associated with treatment failures. Implant removal or replacement was required in most of the cases to eradicate the infection. Conclusion:The most common bacteria which were isolated included Staphylococcusaureus ,followedbyPseudomonas aeruginosa and Klebsiella. A majority of them are resistant to the commonlyusedantibiotics, leading to treatment failures which necessitated an implant removal.
机译：背景：尽管骨科器械相关感染的发生率已降低到1％，但如今，器械相关感染仍是诊断，治疗和成本相关的问题。目的和目的：记录常见的致病性生物体和危险因素三级教学医院的骨科器械相关感染的检查。方法：在一项前瞻性研究中，自2009年1月起对50例接受了骨科器械植入的患者进行了研究。入选2010年6月;其中，并发感染42例。记录每位患者的人口统计学，微生物学数据，治疗方法和结局。统计分析：根据频率和百分比分析数据。结果：在50个样本中，有42个（84％）为培养阳性，而8个（16％）为阴性。在男性（中位年龄37.1岁）和女性（中位年龄41.3岁）中，股骨是最常见的骨。金黄色葡萄球菌是最常见的生物，其引起生物膜形成，其次是非发酵的革兰氏阴性杆菌和克雷伯菌。据我们所知，我们报道了迄今为止念珠菌假丝酵母的文献中第一例。没有分离出厌氧菌。发现组织创伤，开放性骨折，术后手术部位感染和糖尿病是重要的危险因素。形成生物膜的生物通常与微生物感染有关，甚至积极的抗生素治疗也常常不足以消除感染。保守的手术治疗与治疗失败有关。在大多数情况下，需要根除或更换种植体以根除感染。结论：分离出的最常见细菌包括金黄色葡萄球菌，铜绿假单胞菌和克雷伯菌。它们中的大多数对常用的抗生素具有抗性，导致治疗失败，这需要去除植入物。

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