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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Study of Electrocardiographic Changes in Patients of Acute Mania Receiving Verapamil or Lithium Carbonate
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Comparative Study of Electrocardiographic Changes in Patients of Acute Mania Receiving Verapamil or Lithium Carbonate

机译：维拉帕米或碳酸锂急性躁狂患者心电图变化的比较研究

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Aim: TO compare the ECG changes in patients of acute mania receiving verapamil and lithium carbonate.Objectives: Verapamil used in resistant manic patients not responding to any drug therapy, should be considered for its side effects on cardiovascular system. It causes bradycardia and myocardial infarction in risk patients. So it is important to take clinical and other relevant history and do ECG before the patient to put on verapamil drug therapy.Materials and Methods: Patients with acute mania were randomized to receive lithium (n =25) or verapamil (n=25) in a 4-wk double-blind comparative study. Both groups were homogeneous with regard to demographic and disease variables. After giving first dose of verapamil, patients were observed for any cardiovascular side effects and ECG changes during the study. The study parameters were recorded at the baseline, after 7 d and 28 d of trial medication.Statistical Analysis: The Unpaired t-test was used for comparing baseline data in two groups and paired t-test was used for the interval data. A level of less than 5% value of p was considered statistically significant.Results: Both treatment groups showed no major differences in ECG changes during the trial except for the heart rate and T wave changes. The study showed that verapamil produces more bradycardia and T wave depression than with lithium in the treatment of mania.Conclusion: The baseline electrocardiogram should be done and heart rate should be monitored during the treatment.
机译：目的：比较接受维拉帕米和碳酸锂治疗的急性躁狂症患者的心电图变化。目的：对于对任何药物治疗无反应的耐药性躁狂患者使用维拉帕米，应考虑其对心血管系统的副作用。它会在高危患者中引起心动过缓和心肌梗塞。因此，在接受维拉帕米药物治疗之前，应具有临床及其他相关病史并进行心电图检查。材料与方法：急性躁狂症患者被随机分配接受锂（n = 25）或维拉帕米（n = 25）。 4周双盲比较研究。两组在人口统计学和疾病变量方面均相同。在首次服用维拉帕米后，在研究过程中观察患者的任何心血管副作用和心电图变化。在试验药物治疗的第7天和第28天后，在基线记录研究参数。统计分析：未配对t检验用于比较两组的基线数据，配对t检验用于间隔数据。结果表明：p值小于5％的水平具有统计学意义。结果：除心率和T波变化外，两个治疗组在试验过程中的ECG变化均无重大差异。研究表明，维拉帕米治疗躁狂症比锂离子疗法产生更多的心动过缓和T波抑郁。结论：治疗期间应做基线心电图检查并监测心率。

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