Age-related macular degeneration (AMD) is the leading cause of blindness in older adults. Oxidative damage is likely to occur in an environment of extremely high oxygen tension, such as centre of macula, which has continuous and lifelong exposure to radiation. The evaluation of alteration in plasma malondialdehyde (MDA) levels in AMD has been made. Significantly higher MDA levels were detected in patients with AMD when compared with controls (p<0.001).The result supports the role of oxidative damage in the pathogenesis of age related macular degeneration.
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