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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Lower Respiratory Tract Infections (LTRIs): An Insight into the Prevalence and the Antibiogram of the Gram Negative, Respiratory, Bacterial Agents
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Lower Respiratory Tract Infections (LTRIs): An Insight into the Prevalence and the Antibiogram of the Gram Negative, Respiratory, Bacterial Agents

机译：下呼吸道感染（LTRIs）：革兰氏阴性，呼吸道，细菌制剂的患病率和抗菌谱的见解

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Background: Community acquired respiratory tract infections are one of the commonest health issues globally, which de mand frequent visits to the family practitioners. The emergence of antibiotic resistance in the frequently isolated pathogens has complicated the use of the empiric therapy with traditional agents. Aim:This study was focused on obtaining a comprehensive insight into the microbial profile, its prevalence and the susceptibility patterns of the gram negative bacilli isolates in lower respiratory tract infections. Methods and Materials:Respiratory samples which were received from the patients at a Medical College Hospital in North Kerala, India were processed according to the standard protocol over a period of one year, from April 2011 to March 2012. The antimicrobial susceptibility was tested by the Kirby-Bauer disc diffusion method as per the CLSI guidelines. The data was interpreted by using the WHO Net antibiotic susceptibility surveillance software.Results:Out of 1750 respiratory samples, 298(17.03%) were culture positive for gram negative bacilli. The highest isolation rate was observed in the 61-80 years age group with a male pre-ponderance and Klebsiella pneumoniae(41.95%) was found tobe the predominant organism. The resistance pattern varied for different organisms. Among the different groups of antibacterial agents which were ested, levofloxacin was found to be an effective oral antibacterial against the pathogens which wereisolated. The carbapenems (imipenem and meropenem), the betalactum/betalactamase inhibitors (piperacillin/tazobactum)and the aminoglycosides (amikacin) were effective among the parenteral antibacterials. The selection of the appropriate anti-bacterial therapy should be based on the organisms which are isolated and on the emerging resistance to the conventionaltherapies.Conclusion:Owing to the increased concern which surrounds anti bioticresistance and the changing patterns of the bacterial pathogens, the ongoing surveillance of disease and a regularreview of the management guidelines are critical.
机译：背景：社区获得性呼吸道感染是全球最常见的健康问题之一，需要经常拜访家庭医生。在经常分离的病原体中，抗生素耐药性的出现使传统药物与经验疗法的使用变得复杂。目的：本研究的重点是获得对下呼吸道感染中革兰氏阴性杆菌分离物的微生物谱，其流行程度和敏感性模式的全面了解。方法和材料：自2011年4月至2012年3月，在一年的时间内，按照标准协议处理了从印度北喀拉拉邦医学院附属医院患者那里收集的呼吸道样品。根据CLSI准则的Kirby-Bauer光盘扩散方法。结果：使用WHO Net抗生素敏感性监测软件对数据进行解释。结果：在1750份呼吸道样本中，有298份（17.03％）的革兰氏阴性菌培养阳性。在以男性为主的61-80岁年龄组中，隔离率最高，发现肺炎克雷伯菌（41.95％）是主要生物。抵抗模式因不同生物而异。在被评估的不同组抗菌剂中，左氧氟沙星被发现对分离出的病原体是有效的口服抗菌剂。碳青霉烯类（亚胺培南和美洛培南），β-乳清/β-内酰胺酶抑制剂（哌拉西林/他唑巴坦）和氨基糖苷（阿米卡星）在肠胃外抗菌药中有效。适当的抗菌疗法的选择应基于分离出的微生物以及对常规疗法的新出现的耐药性。结论：由于人们越来越关注抗菌素耐药性和细菌病原体的变化，因此需要进行持续的监测疾病的预防和定期检查管理指南至关重要。

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