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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry
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Analysis of Salivary Antioxidant Levels in Different Clinical Staging and Histological Grading of Oral Squamous Cell Carcinoma: Noninvasive Technique in Dentistry

机译：口腔鳞状细胞癌不同临床分期和组织学分级中唾液抗氧化水平的分析：牙科非侵入性技术

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Objective: To estimate and Compare of salivary antioxidant level {Uric acid (UA), Glutathione S Transferase (GST) and Superoxide dismutase (SOD)} between healthy control and study group (oral squamous cell carcinoma patients).Further comparison of sub division of study group on the basis of clinical staging and histological grading.Materials and Methods: The study group consists of 50 cases of squamous cell carcinoma and 50 healthy patients. These parameters were estimated by spectrophotometer. The biochemical values of this study were subjected to statistical analysis i.e. Independent t-test, ANOVA and Tukey test.Result: UA suggested statistically significant changes in saliva of clinical staging and histological grading of oral squamous cell carcinoma (SCC) patients. Salivary SOD level between well to poorly differentiated SCC showed a progressive increase although it is not statistically significant.Conclusion: Salivary analysis of antioxidant is simple, non-invasive technique which may be useful as diagnostic, prognostic and therapeutic marker.
机译：目的：评估和比较健康对照组和研究组（口腔鳞状细胞癌患者）的唾液抗氧化剂水平{尿酸（UA），谷胱甘肽S转移酶（GST）和超氧化物歧化酶（SOD）}。材料与方法：研究组由50例鳞状细胞癌和50例健康患者组成。这些参数通过分光光度计估算。结果：UA提示口腔鳞状细胞癌（SCC）患者临床分期和组织学分级具有统计学意义的唾液变化，并进行了统计学分析，即独立t检验，ANOVA和Tukey检验。唾液中SOD水平在分化良好的SCC和分化较差的SCC之间呈逐渐增加的趋势，尽管无统计学意义。结论：唾液抗氧化剂的分析是一种简单，无创的技术，可作为诊断，预后和治疗的标志物。

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