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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion
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Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion

机译：Ghrelin：Ghrelin作为生长激素分泌中的调节肽

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Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.Objective: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends to explore the possible physiological role of the ghrelin-pituitary-GH axis linkage system.Observation: Ghrelin is highly conserved among species and is classified into octanoylated (C8:0), decanoylated (C10:0), decenoylated (C10:1) and nonacylated,ghrelin. Acylated ghrelin is the major active form of human ghrelin. The primary production site of ghrelin is the stomach, and it interacts with stomach ghrelin as well as hypothalamic GHRH and somatostatin in the regulation of pituitary GH secretion. Ghrelin stimulate GH release through the GHS receptor to increase intracellular Ca2+ ([Ca2+] levels via IP3 signal transduction pathway. Ghrelin is a specific endogenous ligand for the GHS receptor and provides a definitive proof of the occurance of a GHS?GHS receptor signalling system in the regulation of GH secretion.Conclusion: Studies suggests that ghrelin is a powerful pharmacological agent that exerts a potent, time-dependent stimulation of pulsatile secretion of GH.
机译：背景：Ghrelin是一种刺激GH释放的生长激素（GH）促分泌素。目的：这篇综述着重指出了生长素释放肽与GHRH和生长抑素的相互作用，以调节GH的分泌，并试图探讨生长素释放肽-垂体-GH轴连接系统的可能生理作用。 ：Ghrelin在物种中是高度保守的，并且被分类为辛酰化的（C8：0），去酰化的（C10：0），去癸酰化的（C10：1）和未酰化的ghrelin。酰化的生长素释放肽是人类生长素释放肽的主要活性形式。生长激素释放肽的主要产生部位是胃，它与胃生长激素释放肽以及下丘脑GHRH和生长抑素相互作用，调节垂体GH的分泌。 Ghrelin刺激通过GHS受体释放GH，从而通过IP3信号转导途径增加细胞内Ca2 +（[Ca2 +]水平。Ghrelin是GHS受体的一种特异内源性配体，为GHS？GHS受体信号传导系统的存在提供了确定的证据。结论：研究表明生长素释放肽是一种强大的药理剂，可对GH的搏动性分泌产生有效的，时间依赖性的刺激。

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