• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Association of Elevated firstTrimester Serum Uric Acid Levelswith Development of GDM
【24h】

Association of Elevated firstTrimester Serum Uric Acid Levelswith Development of GDM

机译：妊娠前三个月血清尿酸水平升高与GDM发生的关联

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Early intervention and appropriate treatment in patients with GDM will help in preventing the adverse maternal and fetal outcome and protect them from long term complications. Several studies have shown the association of hyperuricemia with GDM. This study was undertaken to find out the association of elevated first trimester uric acid with development of GDM.Materials and Methods: This prospective observational study was conducted in Mahatma Gandhi Medical Collage and Research Institute, Pondicherry, India, between November 2010 and May 2012. A total of 70 pregnant women were included and parameters like age, parity, BMI, history of DM, serum uric acid at <15 weeks and at 24 to 28 weeks and one step test at 24 to 28 weeks were noted and compared.Results: There was no significant correlation between the demographic variables and GDM, but a moderate significance noted between the family history of DM and one step test (p=0.048). Though there is a proportional increase in the serum uric acid with increase in the BMI, it was not statistically significant. A significant correlation was seen between BMI and risk of development of GDM (p= 0.001). Though there is a significant correlation between serum uric acid at <15 weeks and at 24 to 28 weeks, serum uric acid at <15 weeks of gestation is a better predictor of GGI and GDM (Pearson?s correlation = 0.735).Conclusion: There is increase in the risk of development of GDM with increased levels of serum uric acid in the first trimester. Uric acid levels at <15 weeks of gestation is more significantly associated with risk of development of GDM than it?s levels at 24 to 28 weeks of gestation.
机译：背景：对GDM患者的早期干预和适当治疗将有助于预防不良的母婴结局并保护他们免受长期并发症的困扰。几项研究表明高尿酸血症与GDM相关。这项研究的目的是找出妊娠前三个月尿酸水平升高与GDM发生的关系。材料与方法：这项前瞻性观察研究于2010年11月至2012年5月在印度蓬迪切里圣雄甘地医学拼贴研究所进行。总共包括70名孕妇，并记录并比较了年龄，胎次，BMI，DM史，<15周和24-28周时的血清尿酸以及24-28周时的一步测试等参数。人口统计学变量与GDM之间无显着相关性，但在DM家族史和一步检验之间存在中等显着性（p = 0.048）。尽管血清尿酸与BMI的增加成比例增加，但在统计学上无统计学意义。在BMI与GDM发生风险之间存在显着相关性（p = 0.001）。尽管在<15周和24至28周时血清尿酸之间存在显着相关性，但在妊娠<15周时血清尿酸是GGI和GDM的较好预测指标（Pearson相关系数= 0.735）。妊娠初期血清尿酸水平升高会增加GDM发生的风险。与妊娠24至28周时相比，妊娠<15周时尿酸水平与GDM发生风险的相关性更高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号