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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Short Term Comparative Evaluation of Antimicrobial Efficacy of Tooth Paste Containing Lactoferrin, Lysozyme, Lactoperoxidase in Children with Severe Early Childhood Caries: A Clinical Study
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Short Term Comparative Evaluation of Antimicrobial Efficacy of Tooth Paste Containing Lactoferrin, Lysozyme, Lactoperoxidase in Children with Severe Early Childhood Caries: A Clinical Study

机译：严重乳牙患儿含乳铁蛋白，溶菌酶，乳过氧化物酶的牙膏的抗菌功效短期比较评估：一项临床研究

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Background and Objectives: The present study is conducted to compare the anti-microbial efficacy of tooth paste containing lactoferrin, lysozyme, lactoperoxidase (BioXtra ?), a 500ppm fluoride tooth paste, and a non fluoridated tooth paste in children with Severe Early Childhood Caries (S-ECC).Materials and Methods: Study group included 30 children with S-ECC aged 3-5 years. Subjects were randomly selected & divided into three groups of ten each. Group I: Non?fluoride tooth paste, Group II: 500 ppm fluoride tooth paste, Group III: tooth paste containing lactoferrin, lysozyme & lactoperoxidase. Estimation of salivary S. mutans and L. acidophilus levels was accomplished by collecting salivary samples and inoculated on Mitis Salivarius Bacitracin agar (MSB) and Rogosa SL media. Colony Forming Units (CFUs) were counted and the results were tabulated and subjected to statistical analysis.Results: Brushing with tooth paste containing lysozyme, lactoferrin and lactoperoxidase after a week showed highly significant reduction in the CFU counts of both salivary S. mutans and L. acidophilus (p<0.001), whereas 500ppm fluoride tooth paste showed a highly significant reduction in the S. mutans levels (p<0.001), but a significant reduction in L.acidophilus count (p<0.01). Non-fluoride tooth paste showed a highly significant reduction in S. mutans (p<0.001) only, but reduction in the L.acidophilus levels was insignificant (p<0.05).Conclusion: The present study revealed that tooth paste containing lactoferrin, lysozyme, and lactoperoxidase was highly significant in reducing the salivary levels of mutans Streptococci and L.acidophilus in children with S-ECC.
机译：背景与目的：本研究旨在比较含有乳铁蛋白，溶菌酶，乳过氧化物酶（BioXtra？），500ppm氟化物牙膏和非氟化牙膏的牙膏对患有严重幼儿龋齿的儿童的抗菌功效（材料和方法：研究组包括30名3-5岁的S-ECC儿童。随机选择受试者并将其分成三组，每组十个。第一组：非氟化物牙膏，第二组：500 ppm氟化物牙膏，第三组：含有乳铁蛋白，溶菌酶和乳过氧化物酶的牙膏。通过收集唾液样本并将其接种在唾液中的Mitis Salivarius杆菌肽琼脂（MSB）和Rogosa SL培养基中，可以估算唾液变形链球菌和嗜酸乳杆菌的水平。结果：计数含唾液溶酶，乳铁蛋白和乳过氧化物酶的牙膏刷牙一周后，唾液变形链球菌和L.CFU的CFU计数大大降低。 ·嗜酸乳杆菌（p ＜0.001），而500ppm氟化物牙膏显示变形链球菌水平高度显着降低（p ＜0.001），但是嗜酸乳杆菌计数显着降低（p ＜0.01）。非氟化物牙膏仅表现出变形链球菌的高度显着降低（p <0.001），而嗜酸乳杆菌的降低却不显着（p <0.05）。结论：本研究表明牙膏中含有乳铁蛋白，溶菌酶，而乳过氧化物酶在降低S-ECC儿童的唾液中变形链球菌和嗜酸乳杆菌的唾液水平方面具有重要意义。

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