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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Tumour Cellularity in Locally Advanced Breast Carcinoma onNeo-Adjuvant Chemotherapy
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Study of Tumour Cellularity in Locally Advanced Breast Carcinoma onNeo-Adjuvant Chemotherapy

机译：新辅助化疗治疗局部晚期乳腺癌肿瘤细胞的研究

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Background: Breast cancer is the most common invasive malignancy which occurs in women worldwide. The advent of neoadjuvant chemotherapy has radically changed the management of locally advanced breast cancer and a complete response is reported to significantly improve disease free survival. Traditionally, clinical response is assessed on basis of tumour size. In this study, an attempt was made to check whether tumour cellularity could be a better prognostic factor and also to check as to what impact the correlation of tumour size with cellularity had on the response assessment in locally advanced breast cancer patients. Materials and Methods: Thirty seven patients with locally advanced breast cancer, who were treated by neoadjuvant chemotherapy during the period of December 2008 to May 2009, were selected for the study and from their case records, tumour size, clinical response and demographic details were gathered. Tumour cellularity was assessed prior to chemotherapy in core needle biopsy sections and it was matched with that seen in subsequent mastectomy specimens. Tumour size and cellularity were then correlated with the different treatment response groups and they were statistically analyzed by using the SPSS, version 13.0 software. Results: After neoadjuvant chemotherapy, the tumour size and cellularity were found to be significantly reduced in breast carcinomas (p<0.05,paired t-test). The relative changes in cellularity which were seen were highly variable between individual patients and different clinical response groups, particularly in the partial response and no response categories. The product of cellularity and size dramatically changed the distribution of residual tumour pathology, thus causing a shift towards a complete response. Conclusion: The current study showed that the product of tumour size and cellularity may be a better prognostic indicator of clinical response in patients with neoadjuvant chemotherapy treated locally advanced breast cancer and that it would enable a new definition for clinical response in the future.
机译：背景：乳腺癌是最常见的侵袭性恶性肿瘤，发生在全世界的女性中。新辅助化疗的出现从根本上改变了局部晚期乳腺癌的治疗方法，据报道，完全缓解可显着改善无病生存期。传统上，根据肿瘤大小评估临床反应。在这项研究中，尝试检查肿瘤细胞数量是否可能是更好的预后因素，并检查肿瘤大小与细胞数量的相关性对局部晚期乳腺癌患者反应评估的影响。材料与方法：选择2008年12月至2009年5月期间接受新辅助化疗的37例局部晚期乳腺癌患者作为研究对象，并从病例记录，肿瘤大小，临床反应和人口统计学资料中进行收集。 。在核心穿刺活检部分进行化疗之前，评估了肿瘤细胞的形成，并与随后的乳房切除术标本中观察到的相匹配。然后将肿瘤大小和细胞密度与不同的治疗反应组相关联，并使用SPSS 13.0版软件对它们进行统计分析。结果：新辅助化疗后，发现乳腺癌的肿瘤大小和细胞数量显着减少（p <0.05，配对t检验）。在个体患者和不同的临床反应组之间，尤其是在部分反应和无反应类别中，观察到的细胞性的相对变化是高度可变的。细胞大小和大小的乘积极大地改变了残余肿瘤病理的分布，从而导致了向完全应答的转变。结论：目前的研究表明，肿瘤大小和细胞数量的乘积可能是新辅助化疗治疗局部晚期乳腺癌患者更好的临床反应预后指标，并将为将来的临床反应提供新的定义。

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