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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Status of Homocysteine in Polycystic Ovary Syndrome (PCOS)
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Status of Homocysteine in Polycystic Ovary Syndrome (PCOS)

机译：同型半胱氨酸在多囊卵巢综合征（PCOS）中的地位

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age and is estimated to affect 5-10 % of the population. Women with PCOS have a clustering of cardiovascular risk factors, such as obesity, dyslipidemia, impaired glucose tolerance and hypertension. Homocysteine has been recognized recently as a risk factor for cardiovascular diseases. Preliminary investigations suggest that high sensitivity C-reactive protein, homocysteine and adiponectin are abnormal in women with PCOS. The possible determinants of elevated homocysteine concentration are still debated among authors who found significant correlations between homocysteine and insulin resistance or hyperandrogenism.Aim: The purpose of this study is to evaluate homocysteine levels in the PCOS population compared with controls.Materials and Methods: Study group comprised of 142 women with PCOS and 65 healthy non-PCOS controls. Body mass index (BMI), Waist circumference and serum homocysteine were measured in PCOS subjects and age matched controls. Statastical Analysis: All values are expressed as mean ± SD. The results obtained are analysed statistically using the unpaired student t-test to evaluate the significance of differences between the mean values.Results: The mean BMI, Waist circumference and serum homocysteine values are significantly increased in PCOS subjects when compared with non PCOS controls.Conclusion: The present study has demonstrated increase in mean serum homocysteine concentrations in women with PCOS.
机译：背景：多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病，估计会影响5-10％的人口。患有PCOS的女性有很多心血管危险因素，例如肥胖，血脂异常，葡萄糖耐量降低和高血压。同型半胱氨酸最近被认为是心血管疾病的危险因素。初步研究表明，患有PCOS的女性高敏C反应蛋白，高半胱氨酸和脂联素异常。研究者发现同型半胱氨酸浓度升高与可能的决定因素有关，他们发现同型半胱氨酸与胰岛素抵抗或高雄激素血症之间存在显着相关性。由142名患有PCOS的妇女和65名健康的非PCOS对照组成。在PCOS受试者和年龄匹配的对照组中测量体重指数（BMI），腰围和血清同型半胱氨酸。统计学分析：所有值均表示为平均值±SD。使用未配对的学生t检验对获得的结果进行统计学分析，以评估平均值之间差异的显着性。结果：与非PCOS对照相比，PCOS受试者的平均BMI，腰围和血清高半胱氨酸值显着增加：本研究表明，患有PCOS的女性平均血清高半胱氨酸浓度增加。

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