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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Evaluation of Tubex Tf (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area
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Comparative Evaluation of Tubex Tf (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area

机译：结核病Tf（抑制磁结合免疫测定）对地方性伤寒的比较评价

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Background: Typhoid fever remains a significant health problem in endemic countries like India. Various serological tests for the diagnosis of typhoid fever are available commercially. We assessed the usefulness of rapid test based on magnetic particle separation to detect Immunoglobulin against Salmonella typhi O9 lipopolysaccharide. Aim: Aim of this study was to compare the sensitivity and specificity of widal test, typhidot and tubex TF test for the diagnosis of typhoid fever in an endemic country like India. Materials and Methods: Serum samples collected from 50 patients of typhoid fever, 50 patients of non typhoid fever and 100 normal healthy individuals residing in Amritsar were subjected to widal test, typhidot test and tubex TF test as per manufacturer?s instructions. Data collected was assessed to find sensitivity and specificity of these tests in an endemic area. Results: Significant widal test results were found positive in 68% of patients of typhoid fever and only 4% of non typhoid fever patients. Typhidot (IgM or IgG) was positive in 72% of typhoid fever patients and 10% and 6% in non typhoid fever and normal healthy individuals respectively. Tubex TF showed higher sensitivity of 76% and specificity of 96-99% which was higher than typhidot and comparable to widal test. Conclusion: This was the first evaluation of rapid tubex TF test in northern India. In countries which can afford high cost of test, tubex TF should be recommended for the diagnosis in acute stage of the disease in clinical setting. However, there is urgent need for a highly specific and sensitive test for the diagnosis of typhoid fever in clinical settings in endemic areas.
机译：背景：伤寒仍然是印度等流行国家的主要健康问题。商业上可获得用于诊断伤寒的各种血清学测试。我们评估了基于磁性粒子分离的快速测试的有效性，以检测针对伤寒沙门氏菌O9脂多糖的免疫球蛋白。目的：本研究的目的是比较在印度这样的流行国家中，widal试验，伤寒和结节TF试验对伤寒诊断的敏感性和特异性。材料和方法：根据制造商的指示，对50例伤寒患者，50例非伤寒患者和100名居住在阿姆利则的正常健康人的血清样本进行了维德氏测试，伤寒测试和tubex TF测试。对收集的数据进行评估，以发现这些检测在地方性地区的敏感性和特异性。结果：68％的伤寒患者和4％的非伤寒患者都发现了显着的淋巴测试结果。伤寒患者的伤寒（IgM或IgG）阳性，非伤寒患者和正常健康个体的伤寒（IgM或IgG）分别为10％和6％。 Tubex TF显示出76％的更高敏感性和96-99％的特异性，高于伤寒且与韦达尔试验相当。结论：这是印度北部对结核分枝杆菌快速检测的首次评估。在可以承受高昂测试费用的国家，应建议在临床环境中建议使用tubex TF诊断疾病的急性期。但是，迫切需要在流行地区的临床环境中诊断伤寒的高特异性和灵敏性测试。

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