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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Spectrum of Factors Triggering Endothelial Dysfunction in PIH
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Spectrum of Factors Triggering Endothelial Dysfunction in PIH

机译：引发PIH内皮功能障碍的因素谱

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Introduction: Pre-eclampsia (PE) is a major cause of maternal and fetaleonatal mortality and morbidity. The aetiology and pathogenesis of PE is yet to be completely understood. Evidence shows that, Endothelial Dysfunction (ED) plays a pivotal role in the genesis of this multi-system disorder that develops in PE and eclampsia.Aim: To determine the circulating levels of factors Malondialdehyde (MDA), Ferric Reducing Ability of Plasm-a (FRAP), Tumour Necrosis Factor. (TNF-a), sFlt-1, VEGF, PlGF, Nitric Oxide (NO) that influence the ED.Materials and Methods: Study groups consisted of Normotensive pregnant women (N) preclamptic women (PE) and eclamptic women (E) with 100 subjects in each group in the 3rd trimester of pregnancy. They were investigated for MDA, FRAP, TNF-a, sFlt-1, VEGF, PlGF, NO. Statistical analysis was done using Analysis of Variance (ANOVA).Results: When compared to controls MDA, TNF-a, sFlt-1 levels were found to be significantly high and FRAP, VEGF, PIGF and NO levels were significantly low in PE, E group. E showed a significantly high level of MDA, TNF-a, sFlt-1 and low levels of FRAP, VEGF, PIGF, NO when compared to PE group.Conclusion: Our study substantiated the fact, that, oxidative stress, imbalance between anti-angiogenic factors and pro- angiogenic factors exists in Pregnancy Induced Hypertension (PIH) condition. This imbalance is directly related to the ED, the hallmark of PE. So oxidative stress, VEGF, PlGF and sFlt-1 can be used as markers to analyze the onset and progression of the disease.
机译：简介：先兆子痫（PE）是孕产妇和胎儿/新生儿死亡率和发病率的主要原因。 PE的病因和发病机制尚未完全了解。有证据表明，内皮功能障碍（ED）在PE和子痫发展的多系统疾病的发生中起着关键作用。目的：确定丙二醛（MDA），血浆铁蛋白还原铁能力的循环水平（FRAP），肿瘤坏死因子。 （TNF-a），sFlt-1，VEGF，PlGF，一氧化氮（NO）影响ED。材料和方法：研究组由血压正常的孕妇（N）子痫前期妇女（PE）和子痫性妇女（E）组成。妊娠第三个中期每组100名受试者。研究了它们的MDA，FRAP，TNF-α，sFlt-1，VEGF，PlGF，NO。结果：与对照组MDA相比，PE，E中的TNF-a，sFlt-1水平显着偏高，而FRAP，VEGF，PIGF和NO水平显着偏低。组。与PE组相比，E显示出较高的MDA，TNF-α，sFlt-1水平和低水平的FRAP，VEGF，PIGF，NO水平。结论：我们的研究证实了以下事实：氧化应激，抗氧化剂之间的失衡血管生成因子和促血管生成因子存在于妊娠高血压综合征（PIH）中。这种不平衡与PE的标志ED直接相关。因此，氧化应激，VEGF，PlGF和sFlt-1可用作分析疾病发作和进展的标志物。

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