The role of vitamin D in bone homeostasis is well known but nowadays, its role in various essential body processes including prevention of various infective and chronic illnesses like Tuberculosis (TB), by facilitating adaptive and innate immunity in lungs and peripheral blood, is being a matter of debate. Low levels have been associated with respiratory tract infections like TB. Present study aimed to evaluate the level of vitamin D in tubercular patients.Aim: To determine serum vitamin D level in patients with TB and compare it with controls. To compare serum vitamin D level among different types of TB, including Pulmonary TB (PTB), tubercular lymphadenitis and tubercular pleural effusion.Materials and Methods: The present study was a single centre cross-sectional study done during the study period from September 2013 to September 2016 at a tertiary care centre of Uttar Pradesh, India. Total 216 subjects aged between 21 and 60 years were included randomly out of which 113 patients were cases and 103 were controls. Cases of TB were confirmed by sputum Acid Fast Bacilli (AFB) staining, sputum and pleural fluid cytology, Adenosine Deaminase (ADA) of pleural fluid and Fine Needle Aspiration Cytology (FNAC) of lymph nodes. Controls were healthy subjects. Total serum vitamin D levels were measured by Diasorin competitive Radioimmunoassay (RIA) (Autoimmune Diagnostika, GmbH, Strasburg, Germany).Results: The mean serum vitamin D level for patients with TB was 22.4±8.5 ng/mL. Among controls, it was 30.5±8.6 ng/mL (p<0.001). This analysis showed that mean serum vitamin D levels were significantly lower in TB patients as compared with controls and there is no significant difference of serum vitamin D levels in various groups of TB. Also, there was no effect of confounding factors like age, sex and indoor/outdoor activity.Conclusion: The findings of the present study showed that hypovitaminosis-D was highly prevalent among patients with TB as compared to general population in same geographical area and severity of it is not significantly related to different type of TB.
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机译：维生素D在骨骼稳态中的作用是众所周知的，但如今，它在各种基本身体过程中的作用，包括通过促进肺和外周血的适应性和先天免疫力，预防各种感染性和慢性疾病，例如结核病（TB）。辩论的问题。低水平与诸如TB的呼吸道感染有关。本研究旨在评估结核病患者的维生素D水平。目的：确定结核病患者的血清维生素D水平并将其与对照组进行比较。为了比较不同类型的结核病（包括肺结核，结核性淋巴结炎和结核性胸腔积液）中的血清维生素D水平。材料与方法：本研究是在研究期间进行的单中心横断面研究2013年9月至2016年9月，在印度北方邦三级护理中心。随机纳入了216名年龄在21至60岁之间的受试者，其中113例为病例，103例为对照。结核病病例通过痰快速酸杆菌（AFB）染色，痰和胸水细胞学检查，胸水腺苷脱氨酶（ADA）和淋巴结细针穿刺细胞学检查（FNAC）确诊。对照是健康受试者。通过Diasorin竞争放射免疫分析法（RIA）（德国Strasburg，德国，Autoimmune Diagnostika，GmbH）测量血清总维生素D水平。结果：结核病患者的平均血清维生素D水平为22.4±8.5 ng / mL。在对照中，其为30.5±8.6ng / mL（p ＜0.001）。该分析表明，与对照组相比，结核病患者的平均血清维生素D水平显着降低，并且各组结核病患者的血清维生素D水平没有显着差异。另外，没有年龄，性别和室内/室外活动等混杂因素的影响。结论：本研究的结果表明，与相同地理区域的普通人群相比，TB患者中维生素D缺乏症的发病率很高它的面积和严重程度与不同类型的结核病没有明显关系。
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