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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Is Interleukin-18 an Early Diagnostic Biomarker in Contrast Induced Nephropathy?
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Is Interleukin-18 an Early Diagnostic Biomarker in Contrast Induced Nephropathy?

机译：白介素18是造影剂诱发的肾病的早期诊断生物标志物吗？

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The rise in number of cases of hospital-acquired acute kidney injury in patients undergoing diagnostic and therapeutic procedures by the use of contrast medium is a growing concern among nephrologists. Despite being a delayed marker, the measurement of creatinine level is one of the most popular methods in medical fraternity, to identify the degree of damage caused to the kidneys. Therefore there is a need for development of method for early detection and treatment of the contraindication of contrast media. Since serum Interleukin-18 (IL-18) levels rise early in the disease course, it may be a promising novel biomarker and an early indicator of tubular damage as compared to creatinine and other novel biomarkers.Aim: The current study investigated the early rise in serum IL-18 after contrast induction.Materials and Methods: Randomly selected 30 male wistar rats were given 0.6 mL of contrast iohexol (325 mg of iodine per mL) intraperitoneally and blood samples were collected before and after the induction of contrast by bleeding retro-orbital plexuses under isoflurane (USP) inhalation anaesthesia. Blood samples were collected at 3 hours, 6 hours, 12 hours, 24 hours and 48 hours of post-contrast administration. Results were analysed by using paired Student?s t-test and p-value<0.05 was considered to be statistically significant before and after contrast induction.Results: Statistically significant increase in IL-8 levels at 3 (p<0.01), 6 (p<0.001), 12 (p<0.01) and 24 (p 0.07).Conclusion: The present study reveals an increase in IL-18 levels from 48% to 100% at 6 hours post-contrast induct in comparison to other standard markers like creatinine levels which increases at 48-72 hours post-contrast insult, revealed by the literature. Therefore it can be concluded that IL-18 is a better early novel biomarker for tubular damage assessment, after contrast insult.
机译：在肾病专家中，通过使用造影剂进行诊断和治疗的患者中，医院获得性急性肾损伤的病例数增加。尽管是延迟标记，肌酸酐水平的测量还是医学博爱中最流行的方法之一，用于确定对肾脏造成的损害程度。因此，需要开发一种用于早期检测和治疗造影剂禁忌症的方法。由于在疾病过程中血清白细胞介素18（IL-18）水平升高，因此与肌酸酐和其他新型生物标志物相比，它可能是有希望的新型生物标志物和肾小管损害的早期指示物。目的：本研究正在进行中材料与方法：随机选择30只雄性Wistar大鼠，腹腔内给予0.6 mL对比碘海醇（每毫升325 mg碘），并在注射前后收集血样。异氟烷（USP）吸入麻醉下眼眶后丛出血引起的对比剂诱导。造影剂施用后3小时，6小时，12小时，24小时和48小时收集血液样品。使用配对的Student t检验分析结果，在对比剂诱导之前和之后，p值<0.05被认为具有统计学意义。结果：IL-8水平在3时具有统计学意义（p <0.01） ，6（p <0.001），12（p <0.01）和24（p 0.07）。结论：本研究表明，造影剂引入后6小时，IL-18水平从48％增加到100％与其他标准标记物（如肌酐水平）相比，在对比病后48-72小时有所增加，这在文献中有揭示。因此，可以得出结论，在造影剂损伤后，IL-18是用于肾小管损伤评估的更好的早期新型生物标志物。

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