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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients
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Influence of Delivery Devices on Efficacy of Inhaled Fluticasone Propionate: A Comparative Study in Stable Asthma Patients

机译：输送装置对丙酸氟替卡松吸入疗效的影响：稳定哮喘患者的比较研究

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Background: Inhaled corticosteroids are the preferred treatment for long-term control of all grades of persistent asthma. These are administered by various delivery devices with very little information whether these devices can affect the efficacy of inhaled corticosteroids. Fluticasone propionate is a relatively new inhalational corticosteroid compared to older ones like beclomethasone and budesonide.Aims & Objective: To assess the relative efficacy of fluticasone propionate administered from different delivery devices to adult patients of chronic stable bronchial asthma as measured by pulmonary function test parameters.Material and Methods: This prospective study was undertaken to assess the relative efficacy of fluticasone propionate administered from different delivery devices to adult patients of chronic stable bronchial asthma as measured by pulmonary function test parameters. Fourty eight subjects were administered, fluticasone propionate (250 μg) by dry powder inhaler, metered dose inhaler, metered dose inhaler with spacer and fluticasone (1mg) via nebulizer consecutively each week for four weeks under direct supervision. Pulmonary function test was done before and one hour after administration of the drug on each visit.Results: After excluding nine patients who were lost to follow up, data was analysed for the remaining thirty nine patients and no significant difference in peak expiratory flow rate (p=0.77), forced expiratory volume in one second (p=0.95), forced vital capacity (p=0.24) and forced expiratory volume in one second and forced vital capacity ratio (p=0.22) was seen after giving fluticasone by different devices.Conclusion: Fluticasone propionate delivered by different devices like dry powder inhaler, metered dose inhaler, metered dose inhaler with spacer and nebulizer have similar effect on lung function in patients of chronic stable bronchial asthma and may be used interchangeably.
机译：背景：吸入性糖皮质激素是长期控制所有等级持续性哮喘的首选治疗方法。这些是通过各种输送装置进行管理的，很少了解这些装置是否会影响吸入糖皮质激素的功效。丙酸氟替卡松相比于倍氯米松和布地奈德等较老的吸入性皮质类固醇，是一种相对较新的吸入性糖皮质激素。材料和方法：进行这项前瞻性研究，以评估通过肺功能测试参数测量的，从不同的输送装置向成人慢性稳定支气管哮喘患者施用丙酸氟替卡松的相对疗效。在直接监督下，每周连续四周对48名受试者进行干粉吸入器丙酸氟替卡松（250μg），定量吸入器，带垫片的定量吸入器和氟替卡松（1mg）的雾化器给药。每次就诊前和服药后一小时进行肺功能测试。结果：排除9例失去随访的患者后，分析了其余39例患者的数据，且最大呼气流速无明显差异（ p = 0.77），使用不同装置给予氟替卡松后，观察到一秒钟的强制呼气量（p = 0.95），强制的肺活量（p = 0.24）和一秒钟的强制呼气量和强制肺活量比（p = 0.22）。结论：丙酸氟替卡松通过不同的装置（如干粉吸入器，定量吸入器，带间隔器的定量吸入器和雾化器）输送，对慢性稳定支气管哮喘患者的肺功能有相似的影响，可以互换使用。

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