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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Tryptophan Hydroxylase 2 Gene Polymorphism in Anxiety and Depressive Disorder in Kashmiri Population
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Tryptophan Hydroxylase 2 Gene Polymorphism in Anxiety and Depressive Disorder in Kashmiri Population

机译：克什米尔人焦虑和抑郁症的色氨酸羟化酶2基因多态性

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Background: The gene of tryptophan hydroxylase is widely recognized as a major candidate gene in many psychiatric disorders. However, no study has been done which investigates tryptophan hydroxylase 2 gene polymorphism in anxiety and depressive disorders in Kashmiri population (India). Objectives: To study tryptophan hydroxylase 2 (TPH2) C 11993 A gene polymorphism in anxiety and depressive disorders.Method: Sixty patients of depression disorder, 60 patients of anxiety disorder and 40 unrelated healthy volunteers (control) were studied in a case control design. Polymorphism was determined using polymerase chain reaction (PCR) and agarose gel electrophoresis after digestion with HAP II enzyme. Genotypes and allele frequencies were compared using Chi-square tests, Fischer?s exact test, odds ratio, 95% confidence interval (C.I) and p-value of <0.05 was considered to be statistical significant.Results: The mean age ± SD of anxiety, depression and control group was 32.73±10.99, 32.20±10 and 29.75±10.12 respectively and the difference was found to be statistically non significant (p=0.349).The mean HAM-A (Hamilton rating scale for anxiety) score and HAM-D (Hamilton rating scale for depression) score was high in both groups (anxiety and depression) and found to be statistically significant (p=0.001).Depression group had AA genotype (55.2%) than control (37.5%) and was found to be statistically non significant (p=0.890).Comparison of allelic frequency revealed no association of A allele in anxiety group (76.67%) compared with control (75.5%) and was found to be statistically non significant (p= 0.866), OR 1.09 (0.56-2.11).Conclusion: TPH2C 11993 A gene was not found to be associated with major depressive disorder (MDD) and anxiety disorder in Kashmiri population.
机译：背景：色氨酸羟化酶基因被广泛认为是许多精神疾病的主要候选基因。但是，尚未进行研究色氨酸羟化酶2基因多态性在克什米尔人（印度）的焦虑和抑郁症中的研究。目的：研究色氨酸羟化酶2（TPH2）C 11993 A基因多态性与焦虑症和抑郁症的关系。方法：采用病例对照设计，研究了60例抑郁症患者，60例焦虑症患者和40名无关的健康志愿者（对照组）。用HAP II酶消化后，使用聚合酶链反应（PCR）和琼脂糖凝胶电泳确定多态性。使用卡方检验，Fischer精确检验，比值比，95％置信区间（CI）和p值<0.05来比较基因型和等位基因频率具有统计学意义。结果：平均年龄±焦虑，抑郁和对照组的SD分别为32.73±10.99、32.20±10和29.75±10.12，差异无统计学意义（p = 0.349）.HAM-A（汉密尔顿焦虑量表）评分的平均值两组（焦虑和抑郁）和HAM-D（汉密尔顿抑郁量表）得分均较高，且具有统计学意义（p = 0.001）。抑郁组的AA基因型（55.2％）高于对照组（37.5％）。差异无统计学意义（p = 0.890）。等位基因频率的比较显示，与对照组（75.5％）相比，焦虑组（76.67％）与A等位基因没有关联，并且发现统计学上无统计学意义（p = 0.866），或1.09（0.56-2.11）。结论：未发现TPH2C 11993 A基因与克什米尔居民的严重抑郁症（MDD）和焦虑症相关。

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