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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of Short Term CPAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome
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Effect of Short Term CPAP Therapy in Obstructive Sleep Apnea Patients with Metabolic Syndrome

机译：CPAP短期治疗对代谢综合征阻塞性睡眠呼吸暂停的影响

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Background: Patients of obstructive sleep apnea (OSA) with metabolic syndrome (MetS) are at increased risk of cardiovascular morbidity and mortality. The role of oxidative stress in pathogenesis of OSA and MetS has been widely reported. Continuous positive airway pressure (CPAP) therapy remains the first-line of treatment in OSA. The beneficial effect of long term CPAP therapy in OSA is well-known. However, the effect of short term CPAP on the components of MetS and oxidative stress-antioxidant levels is still unclear. Aim: The present study explored the effects of one night of CPAP therapy on the oxidant-antioxidant status and components of MetS in patients of OSA with MetS. Materials and Methods: Twenty adult males and postmenopausal females with MetS and symptoms suggestive of OSA were enrolled in the study. None of the subjects were smoker or alcoholic. They did not consume any drugs that would alter their antioxidant levels. Overnight polysomnography was done to confirm diagnosis and assess CPAP pressure. Following which they spent one night in the sleep lab for CPAP therapy. Blood pressure data and blood samples were collected at baseline and after CPAP. Collected samples were transferred immediately to the laboratory for analysis of serum thiol, lipid peroxidation, insulin resistance (HOMA-IR) and lipid profile. Results: Paired t-test with two-tail significance was used to compare the changes in study parameters in the same patient before and after treatment. The antioxidant level increased and oxidative stress decreased as evidenced by serum thiol concentration (204.2±65.7 vs 254.9±72 μmol/L, p<0.001) and lipid peroxidation levels (13.1±6.2 vs 8.4±3.1 μmol/L, p<0.01).There was a significant decrease in both systolic (132.1±16.1 vs 127.2±14.3 mmHg, p<0.01) and diastolic blood pressure (86.4±9.4 vs 81.2±9.8 mmHg, p<0.01) after one night of CPAP. However, there was no change in lipid parameters and the reduction seen in insulin resistance was not statistically significant. Conclusion: One night of CPAP therapy seems to be helpful in reducing oxidative stress, improving antioxidant levels and decreasing the severity of various components of MetS.
机译：背景：患有代谢综合征（MetS）的阻塞性睡眠呼吸暂停（OSA）患者的心血管疾病发病率和死亡率增加。氧化应激在OSA和MetS发病机理中的作用已被广泛报道。持续气道正压（CPAP）疗法仍然是OSA的第一线治疗方法。长期CPAP治疗OSA的有益作用是众所周知的。然而，短期CPAP对MetS的成分和氧化应激-抗氧化剂水平的影响仍不清楚。目的：本研究探讨了CPAP治疗一晚对患有MetS的OSA患者的氧化-抗氧化状态和MetS组成的影响。材料和方法：纳入20名成年男性和绝经后女性MetS，并表现出OSA症状。没有受试者是吸烟者或酗酒者。他们没有食用任何会改变其抗氧化水平的药物。隔夜进行多导睡眠监测以确诊并评估CPAP压力。之后，他们在睡眠实验室过夜进行CPAP治疗。在基线和CPAP后收集血压数据和血液样本。立即将收集的样品转移到实验室，以分析血清硫醇，脂质过氧化，胰岛素抵抗（HOMA-IR）和脂质谱。结果：采用具有双尾显着性的配对t检验来比较同一患者在治疗前后的研究参数变化。血清硫醇浓度（204.2±65.7 vs 254.9±72μmol/ L，p <0.001）和脂质过氧化水平（13.1±6.2 vs 8.4±3.1μmol/ L，p <0.01）证明抗氧化剂水平升高和氧化应激降低CPAP一晚后收缩压（132.1±16.1 vs 127.2±14.3 mmHg，p <0.01）和舒张压均显着降低（86.4±9.4 vs 81.2±9.8 mmHg，p <0.01）。但是，脂质参数没有变化，胰岛素抵抗的降低在统计学上也不显着。结论：CPAP治疗一晚似乎有助于减轻氧化应激，提高抗氧化剂水平并降低MetS各种成分的严重性。

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