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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Efficacy of Epidural Clonidine with 0.5% Bupivacaine for Postoperative Analgesia for Orthopaedic Lower Limb Surgeries
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Evaluation of Efficacy of Epidural Clonidine with 0.5% Bupivacaine for Postoperative Analgesia for Orthopaedic Lower Limb Surgeries

机译：硬膜外可乐定联合0.5％布比卡因对骨科下肢手术术后镇痛的疗效评估

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Objective: The objective of this study is to evaluate the efficacy of epidural clonidine in intra and postoperative analgesia, the level of sedation caused by clonidine and monitor its side effects. Materials and Methods: Forty patients of ASA1 & ASA2 scheduled for lower limb orthopaediac surgeries were chosen for the study. Study group received 50μg of clonidine diluted to 1ml along with first dose of epidural injection and Control group received 1ml of normal saline along with first dose of epidural. Intra and postoperative vitals, verbal pain rating scale (VRS), sedation score and number of rescue anlgesics required postoperatively were noted. Patients received rescue analgesic when VRS was 1. Results: Addition of clonidine to bupivacaine definitely improves the quality of analgesia by reducing the overall pain score, prolonging the duration of the time of first rescue analgesia and causing reduction of total analgesic consumption in the postoperative period without any hemodynamic instability. Sedation may be beneficial during the intraoperative period. Conclusion: Epidural clonidine produces long lasting, good quality analgesia with good level of sedation and with minimal side effects.
机译：目的：本研究的目的是评估硬膜外可乐定在术中和术后镇痛的疗效，可乐定引起的镇静水平以及监测其副作用。材料和方法：选择计划进行下肢骨科手术的40名ASA1和ASA2患者进行研究。研究组与第一剂硬膜外注射一起接受稀释至1ml的50μg可乐定，对照组与第一剂硬膜外注射接受1ml生理盐水。记录术中和术后的生命体征，言语疼痛等级量表（VRS），镇静分数和术后所需的急救麻醉药数量。当VRS为1时，患者接受了急救镇痛。结果：布比卡因中添加可乐定可通过降低总体疼痛评分，延长首次急诊镇痛时间并导致术后总镇痛药用量减少而明显改善镇痛效果。没有任何血液动力学不稳定。在术中镇静可能是有益的。结论：硬膜外可乐定可产生持久，优质的镇痛效果，镇静作用良好，且副作用最小。

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