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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Detection of Porphyromonas gingivalis fimA Type I Genotype in Gingivitis by Real-Time PCR?A Pilot Study
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Detection of Porphyromonas gingivalis fimA Type I Genotype in Gingivitis by Real-Time PCR?A Pilot Study

机译：实时PCR检测牙龈卟啉单胞菌fimA I型基因型的初步研究

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Introduction: Published literature till date reveals a high prevalence of Porphyromonas gingivalis fimA type I genotype among healthy subjects. Quite a few studies have reported its prevalence also in periodontitis patients. Nevertheless incidence of this genotype in gingivitis is lacking in adult population. Aim: The present study was chosen to detect P. gingivalis fimA type I genotype among chronic gingivitis patients. Materials and Methods: A total of 46 subgingival plaque samples collected from chronic marginal gingivitis (n=23) and chronic periodontitis subjects (control group) (n=23) were subjected to Real-Time Polymerase Chain Reaction to detect the P. gingivalis fimA type I gene. Statistical analysis was performed using chi-square test. Results: Prevalence of P. gingivalis fimA type I gene among chronic periodontitis and chronic gingivitis patients were 8.7% and 30.4% respectively. P. gingivalis fimA type I genotype prevalence was found to be statistically insignificant between the two study groups (p=0.135). Conclusion: The avirulent P. gingivalis fimA type I genotype, occurred in high prevalence among chronic gingivitis patients, while its presence was low in chronic periodontitis patients. Presence of this avirulent genotype in chronic marginal gingivitis signifies its reversible condition.
机译：简介：迄今为止的公开文献显示，健康受试者中牙龈卟啉单胞菌fimA I型基因型的患病率很高。不少研究报道其在牙周炎患者中的患病率。然而，成年人口中缺乏该基因型在牙龈炎中的发生率。目的：选择本研究来检测慢性牙龈炎患者中的牙龈卟啉单胞菌fimA I型基因型。材料与方法：从慢性边缘性牙龈炎（n = 23）和慢性牙周炎受试者（对照组）（n = 23）收集的总共46个牙龈下菌斑样品进行实时聚合酶链反应以检测牙龈假单胞菌I型基因。使用卡方检验进行统计分析。结果：慢性牙周炎和慢性牙龈炎患者中牙龈卟啉单胞菌fimA I型基因的患病率分别为8.7％和30.4％。在两个研究组之间，牙龈卟啉单胞菌的fimA I型基因型患病率在统计学上无统计学意义（p = 0.135）。结论：无毒牙龈假单胞菌fimA I型基因型在慢性牙龈炎患者中高发，而在慢性牙周炎患者中其低发。慢性边缘性牙龈炎中这种无毒基因型的存在表明其可逆性状况。

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