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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of the Use of Single andCombined Antibiotics for Head and NeckOnco-Surgeries: A Cost effective Analysis
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Comparison of the Use of Single andCombined Antibiotics for Head and NeckOnco-Surgeries: A Cost effective Analysis

机译：头颈部肿瘤手术中使用单一和联合抗生素的比较：成本效益分析

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Back ground and Objectives:The use of prophylactic antibiotics in surgical treatment is well-established. However, the duration and the dosage of the prophylaxis vary substantially among the surgeons. Therefore, we intended to explore the differences in the cost efficiency in single and combined antibiotics as the prophylaxis for the surgical treatment of major head and neck onco-surgeries.Methods:50 patients of either gender with head and neck cancer, who were to undergo major surgeries were chosen. The perioperative antibiotic prophylaxis and the antibiotics which were used to treat the post operative wound infections were noted. The data on the drug costs were obtained and the cost analysis was performed by comparing the costs which were incurred on using a single antibiotic and combined antibiotics as the prophylaxis. The wound infection controlled days, the time taken for wound healing and the duration of the hospital stay were followed up.Results:22 subjects were on single antibiotic therapy and 28 were on combination therapy. Among those who were on singleantibiotic therapy and combined therapy, 11 (50%) and 7 (25%) had post operative wound infections respectively. The Mean ± SD of the cost which was incurred on using a single antibiotic as the prophylaxis was lesser than (803.15 ± 1104.56 rupees) that which was incurred on using combined antibiotics, i.e 1524.29 ±1468.28 rupees. But, the total cost (for the prophylaxis and the post operatively used antibiotics) had no significant difference between the groups, which used a single antibiotic and combined antibiotic prophylaxis. Among the patients who developed post op infections either with the single antibiotic or with combined antibiotic use, the prophylaxis did not show a significant difference in the total cost which was incurred. Also, it did not make a significant difference in the means of the time which was taken for wound healing.erpretation and Conclusion:There is no significant difference in the total cost which was incurred on using either a single antibiotic or combined antibiotics as the prophylaxis, due to the increased post operative infections in patients who used a single antibiotic as the prophylaxis.
机译：背景和目的：预防性抗生素在外科治疗中的使用已得到公认。然而，预防的持续时间和剂量在外科医生之间大不相同。因此，我们打算探讨单一和联合抗生素在预防主要头颈部肿瘤手术治疗中的成本效率上的差异。方法：50例接受性别治疗的男女头颈部癌患者选择了大手术。注意到围手术期的抗生素预防和用于治疗术后伤口感染的抗生素。获得了有关药物成本的数据，并通过比较使用单一抗生素和联合抗生素作为预防措施产生的成本进行了成本分析。随访伤口感染控制天数，伤口愈合时间和住院时间。结果：单药治疗22例，联合治疗28例。在接受单一抗生素治疗和联合治疗的患者中，术后伤口感染分别为11（50％）和7（25％）。使用单一抗生素进行预防所产生的费用的平均±SD低于使用联合抗生素所产生的费用的平均（152.15±1104.56卢比），即1524.29±1468.28卢比。但是，总费用（用于预防和术后使用抗生素）在使用单一抗生素和联合抗生素预防的组之间没有显着差异。在使用单一抗生素或联合使用抗生素的术后感染患者中，预防措施在总花费上没有显着差异。而且，在伤口愈合的时间上也没有显着差异。结论和结论：使用单一抗生素或联合抗生素作为预防措施所产生的总成本没有显着差异。由于使用单一抗生素预防的患者术后感染增加。

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