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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Osteoarticular Tuberculosis-A ThreeYears? Retrospective Study
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Osteoarticular Tuberculosis-A ThreeYears? Retrospective Study

机译：骨关节结核三年？回顾性研究

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Introduction: Extra pulmonary TB can be encountered in various organ systems, like lymph nodes, serous cavities, genitourinary tract, skeletal. Musculoskeletal TB can cause significant functional impairment. The clinical symptoms are variable, pain and swelling being common symptomatology. Investigations for suspected cases include radiological imaging, histopathological examination, bacteriological examination, and polymerase chain reaction. The mainstay of treatment is multidrug antitubercular chemotherapy.Aims: To study the cases of osteoarticular TB diagnosed on biopsy, to analyse the various microscopic patterns, results of microbiological investigations, correlate the clinical and radiological features and the response to ATT.Settings and Design: A teaching tertiary medical institute in North India in catchment area, where prevalence of tuberculosis is high. A retrospective study of cases with a biopsy diagnosis of bone and/joint TB, retrieved from Histopathology section of Department of Pathology of the tertiary institute.Material and Methods: The study was retrospective and the data was collected for the preceding 3 years. The cases were retrieved from the records of the department of Pathology. A total of 16 cases were diagnosed as/suspected to be tuberculosis of bones and/joints. The clinical information were noted from the case files. Results of laboratory investigations along with relevant microbiologic investigations were noted. The biopsy samples were processed according to protocol. Ziehl?Neelsen stain to detect tubercle bacilli and PAS stain to rule out fungal infection were done. Microscopic features were noted.Results and Conclusion: Sixteen cases with a diagnosis of bone and/joint tuberculosis were found. The average age was 23.6 years. The most common presentation was pain and swelling. Knee joint was most commonly involved (7 cases) followed by spine and ankle (3 each). All the cases showed epithelioid granulomas which was necrotising in 11. AFB positivity was found only in 4 cases. ATT was started in 12 cases with a good response. It is important to suspect osteoarticular TB clinically and investigate accordingly. In resource poor setting, study of biopsy material can aid in diagnosis, further guiding the management.
机译：简介：额外的肺结核可在各种器官系统中遇到，例如淋巴结，浆液腔，泌尿生殖道，骨骼。肌肉骨骼结核可导致严重的功能障碍。临床症状易变，疼痛和肿胀是常见的症状。可疑病例的检查包括放射影像学，组织病理学检查，细菌学检查和聚合酶链反应。治疗的主要手段是多药抗结核化疗。目的：研究经活检诊断出的骨关节结核病例，分析各种微观模式，微生物学检查结果，将临床和放射学特征以及对ATT的反应进行关联。印度北部集水区结核病高发地区的一所教学第三级医学研究所。从第三研究所病理学系组织病理学科检索到的活检诊断为骨和/或关节结核的病例的回顾性研究。材料与方法：该研究是回顾性的，并收集了前3年的数据。从病理科的记录中检索出病例。总共有16例被诊断为/怀疑为骨骼和/或关节结核。从病例档案中记录了临床信息。记录了实验室调查的结果以及相关的微生物学调查。根据协议处理活检样品。 Ziehl？Neelsen染色检测结核杆菌，PAS染色排除真菌感染。结果与结论：共发现16例诊断为骨和/或关节结核的病例。平均年龄为23.6岁。最常见的表现是疼痛和肿胀。膝关节受累最普遍（7例），其次是脊柱和踝关节（各3例）。所有病例均表现为上皮样肉芽肿，其中11例坏死。仅4例发现AFB阳性。 ATT开始治疗12例，反应良好。临床上怀疑骨关节结核并进行相应调查很重要。在资源贫乏的地区，活检材料的研究可以帮助诊断，进一步指导管理。

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