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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Determining the Effect of Gutkha on Serum Levels of Vitamin B12 and Folic Acid as Compared to Smoking among Chronic Periodontitis Subjects : A Cross-Sectional Study
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Determining the Effect of Gutkha on Serum Levels of Vitamin B12 and Folic Acid as Compared to Smoking among Chronic Periodontitis Subjects : A Cross-Sectional Study

机译：确定Gutkha对慢性牙周炎受试者血清维生素B12和叶酸水平的影响（与吸烟相比）：一项跨领域研究

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Background: Periodontitis, being a common inflammatory disease has a multifactorial origin, with smoking and gutkha as few of the causative entities. The role of smoking as a risk factor for periodontitis is been well documented in literature. Cigarette smoke also affects vitamin B12 and folic acid mechanisms. Nutritionally derived vitamin B12 occurs mainly as either hydroxycobalamin or deoxyadenosycobalmin. Folic acid is also heat sensitive and water soluble, closely linked to vitamin B12 in its metabolism. However, effect of smokeless tobacco in form of gutkha on serum levels of vitamin B12 and folic acid is yet to be explored.Aims and Objectives: To estimate and correlate serum vitamin B12 (VB12) and folic acid (FA) levels among periodontally healthy subjects and Chronic Periodontitis (CP) subjects with habit of smoking and gutkha chewing.Materials and Methods: The study included 111 subjects ranging in age from 18 to 60 y. Participants were divided into four groups: 30 healthy subjects (Group I), 29 subjects with CP (Group II), 25 smokers with CP (Group III) and 27 gutkha chewers with CP (Group IV). Clinical parameters included pocket probing depth (PPD), clinical attachment level (CAL) & gingival index (GI) following which VB12 and FA levels were estimated through UV-spectrophotometry method and data was analysed using Statistical Package for Social Scientists software, Mann-Whitney U-test and Pearson correlation coefficient. p-values less than 0.05 were considered as significant.Results : Pairwise comparison by Mann-Whitney U-test showed an increase in the serum VB12 in Group IV when compared to Group I (p=0.01) and Group II (p=0.01). Although serum FA levels were found to be low in Group III (7.61 ug/ml) & Group IV (8.64 ug/ml), Group III was found to be statistically significant (P=0.046). The clinical parameters GI, PPD and CAL among the four groups of patients were also statistically significant (p < 0.05).Conclusion: The study results suggested that among the patients with periodontal disease, serum VB12 levels are directly related while serum FA levels are inversely related to inflammation and tissue destruction in periodontium as occurred in Group IV.
机译：背景：牙周炎是一种常见的炎症性疾病，其起因是多方面的，吸烟和古特卡因是很少的病因。吸烟已成为牙周炎危险因素的作用在文献中已有充分的文献记载。香烟烟雾还会影响维生素B12和叶酸的机制。营养来源的维生素B12主要以羟基钴胺素或脱氧腺苷钴胺素的形式存在。叶酸也是热敏性和水溶性的，在其新陈代谢中与维生素B12密切相关。然而，尚无定型的无烟烟草对血清维生素B12和叶酸水平的影响。目的和目的：评估和关联牙周健康受试者的血清维生素B12（VB12）和叶酸（FA）水平。材料和方法：该研究包括111名年龄在18至60岁的受试者。参与者分为四组：30名健康受试者（I组），29名CP患者（II组），25名吸烟者CP（III组）和27名Gutkha咀嚼者CP（IV组）。临床参数包括口袋探测深度（PPD），临床附着水平（CAL）和牙龈指数（GI），然后通过紫外分光光度法估算VB12和FA水平，并使用统计软件包供社会科学家软件Mann-Whitney分析U检验和Pearson相关系数。 p值小于0.05被认为是显着的。结果：通过Mann-Whitney U检验进行的成对比较显示，与I组（p = 0.01）和II组（p = 0.01）相比，IV组的血清VB12升高。 。尽管在第III组（7.61 ug / ml）和第IV组（8.64 ug / ml）中发现血清FA水平较低，但发现第III组具有统计学意义（P = 0.046）。四组患者的临床参数GI，PPD和CAL也具有统计学意义（p <0.05）。结论：研究结果表明，在牙周病患者中，血清VB12水平直接相关，而血清FA水平成反比。与IV组中发生的牙周炎和组织破坏有关。

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