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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Triple Test in Carcinoma Breast
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Triple Test in Carcinoma Breast

机译：乳腺癌三重检测

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Introduction: The commonest clinical presentation in majority of breast pathology is a lump. A definite diagnosis of breast lump is very important for the surgeon to decide on the final course of treatment and also saves the patient from unnecessary physical, emotional and psychological trauma if there is a definite preoperative diagnosis of benign lesion. The present study was done to evaluate the effectiveness and relevance of ?TRIPLE TEST?in diagnosis of carcinoma breast in rural labour class population.Materials and Methods: The present study was a prospective study conducted on patients over 35 years of age having palpable breast lumps presenting in the out patient department of general surgery, ESI Hospital Basaidarapur New Delhi, india. The duration of study was from May 2007 to June 2009 and a total of 100 cases were studied. Each patient was subjected to a detailed history, clinical breast examination ,diagnostic mammography and FNAC. In this study, the results of each modality was divided in three groups: benign, suspicious and malignant. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of each test was calculated individually and as combined.Result: Out of 100 patients enrolled in this study, 60 cases were benign and 40 cases were of malignant breast disease. The age of patients with carcinoma breast in the series varied from 35 years to 70 years. The highest incidence of malignancy noted was 30% in 41-50 years age group (4th decade) followed by 27.5% in 51-60 years age group (5th decade). The sensitivity of clinical examination was found to be 75%, specificity was 83.3%, positive predictive value (PPV) of 75% and diagnostic accuracy of 80%. The sensitivity, specificity, positive predictive value and diagnostic accuracy of mammography was calculated and was found to be 94.9% , 90% , 86% and 92% respectively. The sensitivity, specificity, positive predictive value and diagnostic accuracy of FNAC was 94.7%, 98.3%, 97.3% and 96.6% respectively. Out of 100 cases triple test was concordant (all three test either benign or malignant) in 80 cases, all the benign cases detected by triple test were benign on final biopsy i.e. 100% specificity and 100% negative predictive value.Conclusion: TTS is an accurate and least invasive diagnostic test based on which definitive treatment can be initiated.
机译：简介：大多数乳腺病理学中最常见的临床表现是肿块。乳房肿块的明确诊断对于外科医生决定最终的治疗过程非常重要，并且如果术前明确诊断为良性病变，还可以使患者免于不必要的身体，情感和心理创伤。本研究旨在评估“三重检验”在农村劳工阶层人群乳癌诊断中的有效性和相关性。材料与方法：本研究是一项针对35岁以上有明显乳房肿块的患者进行的前瞻性研究。在印度新德里Basaidarapur的ESI医院的普外科门诊就诊。研究时间为2007年5月至2009年6月，共研究了100例。每位患者均接受了详细的病史，临床乳房检查，乳腺钼靶诊断和FNAC。在这项研究中，每种方法的结果分为三组：良性，可疑和恶性。结果：本研究共纳入100例患者，其中60例为良性，40例为恶性乳腺疾病，其敏感性，特异性，阳性预测值，阴性预测值和诊断准确性均进行了计算。该系列乳腺癌患者的年龄从35岁到70岁不等。在41-50岁年龄组（第40个十年）中，发现的最高恶性肿瘤发生率为30％，其次在51-60岁年龄组（第5个十年）中占27.5％。临床检查的敏感性为75％，特异性为83.3％，阳性预测值（PPV）为75％，诊断准确性为80％。计算出乳腺X线摄影的敏感性，特异性，阳性预测值和诊断准确性，分别为94.9％，90％，86％和92％。 FNAC的敏感性，特异性，阳性预测值和诊断准确性分别为94.7％，98.3％，97.3％和96.6％。在100例患者中，三重检查结果一致（三个检查均为良性或恶性），在80例中，三重检查发现的所有良性病例在最终活检中均为良性，即100％特异性和100％阴性预测值。准确的，侵入性最小的诊断测试，基于该测试可以开始确定的治疗。

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