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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Blonanserin ? A Novel Antianxiety and Antidepressant Drug? An Experimental Study
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Blonanserin ? A Novel Antianxiety and Antidepressant Drug? An Experimental Study

机译：Blonanserin？一种新型的抗焦虑和抗抑郁药？实验研究

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Introduction: Many psychiatric disorders show signs and symptoms of anxiety and depression. A drug with both, effects and lesser adverse effects is always desired. Blonanserin is a novel drug with postulated effect on anxiety and depression.Aim: The study was aimed to evaluate the effect of Blonanserin on anxiety and depression in animal models.Materials and Methods: By using elevated plus maze test and forced swimming test, the antianxiety and antidepressant effects were evaluated. Animal ethics protocols were followed strictly. Total 50 rats (10 rats per group) were used for each test. As a control drug diazepam and imipramine were used in elevated plus maze and forced swimming test respectively. Blonanserin was tested for 3 doses 0.075, 0.2 and 0.8mg. These doses were selected from previous references as well as by extrapolating human doses.Results: This study showed an antianxiety effect of Blonanserin comparable to diazepam, which was statistically significant. Optimal effect was observed with 0.075mg, followed by 0.2 and 0.8mg. It also showed an antidepressant effect which was statistically significant. Optimal effect was observed at 0.2mg dose.Conclusion: The results showed that at a dose range of 0.075 and 0.2mg Blonanserin has potential to exert an adjuvant antianxiety and antidepressant activity in animal models. In order to extrapolate this in patient, longer clinical studies with comparable doses should be planned. The present study underlines potential of Blonanserin as a novel drug for such studies.
机译：简介：许多精神病患者表现出焦虑和抑郁的体征和症状。一直希望有同时具有作用和较小副作用的药物。 Blonanserin是一种对焦虑和抑郁有假定作用的新型药物。目的：本研究旨在评估Blonanserin在动物模型中对焦虑和抑郁的影响。材料与方法：通过高架迷宫试验和强迫游泳试验，对焦虑症进行研究。并评估抗抑郁作用。严格遵守动物道德规范。每次测试总共使用50只大鼠（每组10只大鼠）。作为对照药物，地西epa和丙咪嗪分别用于高架迷宫和强迫游泳试验。测试勃兰色林的3种剂量为0.075、0.2和0.8mg。这些剂量是从先前的参考文献以及通过推断人类的剂量中选择的。结果：这项研究显示，布洛那色的抗焦虑作用与地西epa相当，具有统计学意义。最佳效果观察为0.075mg，然后分别为0.2和0.8mg。它也显示出抗抑郁作用，在统计学上是显着的。结论：0.2mg剂量时效果最佳。结论：在0.075和0.2mg剂量范围内，Blonanserin具有在动物模型中发挥佐剂抗焦虑和抗抑郁活性的潜能。为了在患者中推断这一点，应计划进行更长的临床研究，并进行相当剂量的研究。本研究强调了Blonanserin作为此类研究的新型药物的潜力。

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