• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Demographic, Clinical and Endoscopic Characteristics of Active and Antibiotic-resistant H. pylori-associated Gastritis in Egyptian Adults
【24h】

Demographic, Clinical and Endoscopic Characteristics of Active and Antibiotic-resistant H. pylori-associated Gastritis in Egyptian Adults

机译：活性和耐药性H的人口统计学，临床和内镜特征。埃及成年人幽门螺杆菌相关性胃炎

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In Egypt the prevalence of H. pylori infection is high up to 90% in adults. Sequels of infection range from asymptomatic colonisation of the gastric mucosa to acute gastritis, chronic gastritis, atrophic gastritis, intestinal metaplasia, dysplasia and cancer. Antimicrobial resistance increases with time and decline in eradication rate reported globally.Aim: To determine demographic, clinical and endoscopic presentation of H. pylori infected Egyptian adults and characteristics of patients resistant to eradication therapy used in Egypt.Materials and Methods: This was a retrospective observational study which included 202 patients who had chronic active H. pylori gastritis and were referred to Internal Medicine Department Endoscopy Unit, Zagazig University Hospital; a tertiary referral centre from June to December 2017. Retrospective analysis of demographic features such as age and sex, clinical presentation, endoscopic features such as distribution of gastritis, nodularity, ulcers, erosions, polyps, Gastroesophageal Reflux Disease (GERD) and duodenitis as well as histological reports were used. Data were computerised and statistically analysed using SPSS program version 24.0.Results: Middle-aged females had more infection and referral for endoscopic evaluation. Persistent epigastric pain is the common presentation. Pan gastritis and diffuse erythematous mottling are the common endoscopic criteria while mucosal nodularity was present in 21.8% especially in females. Mild activity is the more pronounced histological finding. Associated features were the presence of apparent submucosal vasculature (39.6%), erosions (22.8%), ulcers (22.8%), hyperplastic polyps (5.9%), incompetent cardia (89.1%), GERD mainly of Type A (40.6%) and mild duodenitis (52.5%). Resistance to first line therapy was seen in 45.5% of patients. Epigastric pain, the presence of apparent submucosal vasculature and GERD were independently associated with resistant infection (p<0.001, 0.001, 0.001, respectively). False negative stool antigen was present in 22.8%.Conclusion: Females are more affected and presented with persistent epigastric pain and pangastritis type of mild activity. Availability of other antibiotics as the first line eradication therapy is needed. Patients with epigastric pain, apparent submucosal vasculature and GERD have resistant infection and other eradication regimens should be used however larger studies are needed to confirm the same. Improving diagnostic tests to avoid unnecessary endoscopic referral is needed.
机译：在埃及，成人的幽门螺杆菌感染率高达90％。感染的后遗症包括无症状的胃粘膜定植，急性胃炎，慢性胃炎，萎缩性胃炎，肠上皮化生，异型增生和癌症。抗菌素耐药性随时间增加，根除率下降，全球报道。目的：确定感染幽门螺杆菌的埃及成年人的人口统计，临床和内窥镜检查，以及在埃及使用的对根除疗法耐药的患者的特征。材料和方法：这是一项回顾性观察研究，纳入202例患有慢性活动性幽门螺杆菌胃炎的患者，并将其转诊至扎嘎兹格大学医院内科内镜科。于2017年6月至2017年12月成为第三级转诊中心。对年龄，性别，临床表现，内镜特征（如胃炎，结节，溃疡，糜烂，息肉，胃食管反流病（GERD）和十二指肠炎）等人口统计学特征进行回顾性分析因为使用了组织学报告。使用SPSS 24.0版程序对数据进行计算机化和统计分析。结果：中年女性感染率更高，需要转诊进行内镜评估。持续性上腹痛是常见表现。内窥镜检查通常以泛性胃炎和弥漫性红斑斑块为标准，而粘膜结节占21.8％，尤其是女性。轻度活动是最明显的组织学发现。相关的特征是明显的粘膜下脉管系统（39.6％），糜烂（22.8％），溃疡（22.8％），增生性息肉（5.9％），）门不全（89.1％），GERD主要为A型（40.6％）和轻度十二指肠炎（52.5％）。 45.5％的患者对一线疗法有抗药性。上腹疼痛，明显的粘膜下脉管系统和GERD分别与耐药性感染相关（分别为p <0.001、0.001、0.001）。假阴性粪便抗原的存在率为22.8％。结论：女性受影响更大，并表现为持续的上腹痛和胰腺炎类型的轻度活动。需要其他抗生素作为一线根除疗法。上腹部疼痛，明显的粘膜下血管和GERD的患者具有抗药性感染，应采用其他根除方案，但是需要进行更大的研究来证实同样的情况。需要改进诊断测试以避免不必要的内窥镜转诊。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号