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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Osteoporosis at Distal Radius in Otherwise Healthy Adult Patients with Type 2 Diabetes: Does it differ from Routine?
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Osteoporosis at Distal Radius in Otherwise Healthy Adult Patients with Type 2 Diabetes: Does it differ from Routine?

机译：成年健康的2型糖尿病成年患者远端半径的骨质疏松症：与常规不同吗？

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Type 2 Diabetes Mellitus (T2DM) affects bone metabolism at axial as well as the appendicular skeleton. Bone loss may vary at different sites. Besides spine and hip, the distal radius is commonly evaluated for osteoporosis in T2DM. The study represents the findings of osteoporosis at distal radius in otherwise healthy T2DM cases.Aim: To study osteoporosis at distal radius in relation to spine and hip in otherwise healthy T2DM cases.Materials and Methods: In this cross-sectional, observational study, adult patients above 50 years of age with T2DM with no other comorbidities or bone disease were assessed. All patients underwent Bone Mineral Density (BMD) evaluation with Dual-Energy X-Ray Absorptiometry scan (DXA) at spine, hip and distal radius. T-score of <-2.5 was considered as osteoporosis. Student?s t-test and Chi-square test were used to detect statistically significant differences in continuous and categorical data. One-way analysis of variance (ANOVA) was used to compare continuous data in more than two groups. Pearson coefficient was determined to study the correlations. The p-value <0.05 was considered statistically significant.Results: In 200 patients studied, osteoporosis at spine, hip and distal radius was found in 33.5%, 13.5% and 90.0% patients, respectively. Body mass index was significantly lower in patients with radial osteoporosis (p=0.048). There was a significant correlation between osteoporosis at the distal radius and osteoporosis at the spine (p<0.0001) and hip (p<0.0001). As osteoporosis was observed in a large number of patients; we further used T-score =-5.0 cut-off and observed osteoporosis in 37.5% patients. There was no difference in prevalence of osteoporosis in different age groups (p=0.510 and p=0.796) and two genders (p=0.203 and p=0.289) using either cut-off values. Vitamin D deficiency did not differ significantly in patients with or without osteoporosis using either cut-off values (p=0.603 and p=0.582).Conclusion: Compared to spine and hip, the prevalence of osteoporosis was higher at distal radius (90.0%) using standard T-score cut-off (=-2.5). Therefore, distal radius site should be evaluated in all cases for osteoporosis in T2DM. Further research is necessary to study whether bone loss occurs early and faster at distal radius compared to other sites.
机译：2型糖尿病（T2DM）影响轴向和阑尾骨骼的骨代谢。骨丢失可能在不同的位置有所不同。除了脊柱和髋关节外，T2DM中通常评估distal骨远端是否患有骨质疏松症。该研究代表了其他方面健康的T2DM病例在distal骨远端骨质疏松的发现。目的：研究在其他方面健康的T2DM病例在distal骨远端骨质疏松的相关性。材料和方法：在本交叉研究中横断面观察研究评估了50岁以上患有T2DM且无其他合并症或骨病的成年患者。所有患者均在脊柱，髋部和distal骨远端进行了双能量X线骨密度仪扫描（DXA）对骨矿物质密度（BMD）的评估。 T分数<-2.5被认为是骨质疏松症。使用学生t检验和卡方检验来检测连续数据和分类数据的统计学显着差异。使用单向方差分析（ANOVA）比较两组以上的连续数据。确定皮尔逊系数以研究相关性。 p值<0.05被认为具有统计学意义。结果：在研究的200例患者中，分别在33.5％，13.5％和90.0％的患者中发现了脊柱，臀部和distal骨骨质疏松症。 radial骨骨质疏松症患者的体重指数显着降低（p = 0.048）。 radius骨远端骨质疏松症与脊柱骨质疏松症（p <0.0001）和臀部（p <0.0001）之间存在显着相关性。由于在许多患者中观察到骨质疏松症;我们进一步使用T评分= -5.0截止值，并在37.5％的患者中观察到骨质疏松。使用两个截断值，不同年龄组（p = 0.510和p = 0.796）和两个性别（p = 0.203和p = 0.289）的骨质疏松患病率无差异。使用临界值（p = 0.603和p = 0.582），有无骨质疏松症患者的维生素D缺乏症无显着差异。结论：与脊柱和髋关节相比，distal骨远端的骨质疏松症患病率更高（ 90.0％）使用标准的T分数截止（= -2.5）。因此，在所有情况下都应评估radius骨远端部位是否存在T2DM中的骨质疏松症。与其他部位相比，有必要进行进一步的研究以研究骨丢失在distal骨远端是否较早发生并更快。

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