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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronicand Aggressive Periodontitis:A Clinico-Biochemical Study ZC41-ZC45
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Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronicand Aggressive Periodontitis:A Clinico-Biochemical Study ZC41-ZC45

机译：慢性侵袭性牙周炎患者C反应蛋白和纤维蛋白原的评价：一项临床生化研究ZC41-ZC45

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Introduction: Periodontal disease is characterised by chronic infection and inflammation in periodontal tissues leading to destruction of alveolar bone with subsequent tooth loss. Periodontal infections are the result of an interaction between tooth associated microbial biofilms and the host defences. Periodontal pathogens can affect local and systemic immune and inflammatory responses.Aim: The aim of the present study was to evaluate serum C-Reactive Protein (CRP), plasma fibrinogen and peripheral blood levels in healthy subjects, chronic and aggressive periodontitis patients.Materials and Methods: A total of 55 subjects, 27 males and 28 females were selected for the study. Blood samples were taken from healthy controls (n=20) and patients with chronic periodontitis (n=20) and aggressive periodontitis (n=15). The periodontal status of each patient was assessed by recording Oral Hygiene Index-Simplified (OHI-S), Bleeding Index (BI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL). The levels of serum CRP were measured using high sensitivity Enzyme Linked Immunosorbent Assay (ELISA) and levels of plasma fibrinogen were measured using Quantitative Immunoturbidimetric assay. Data description was done in the form of mean and standard deviation and analysis of data was done using one way ANOVA (Analysis of Variance) and Students t-test to test the statistical significance between groups.Results: The levels of serum CRP and plasma fibrinogen was increased in patients with chronic and aggressive periodontitis when compared to healthy controls (p<0.001). A positive correlation was found to exist between levels of clinical parameters like OHI-S, BI, PPD and CAL when compared with CRP and fibrinogen as well as with the study groups.Conclusion: The finding of the present study suggests the role of serum as a diagnostic marker in inflammatory conditions and indicates that levels of CRP and fibrinogen may serve as important biomarkers for evaluating the association between periodontitis and cardiovascular diseases.
机译：简介：牙周疾病的特征是牙周组织的慢性感染和炎症，导致牙槽骨破坏并随后掉牙。牙周感染是牙齿相关微生物生物膜与宿主防御系统相互作用的结果。牙周病原体可以影响局部和全身免疫和炎症反应。目的：本研究旨在评估健康受试者，慢性和侵袭性牙周炎患者的血清C反应蛋白（CRP），血浆纤维蛋白原和外周血水平。方法：共55名受试者，男性27名，女性28名。从健康对照（n = 20）和患有慢性牙周炎（n = 20）和侵袭性牙周炎（n = 15）的患者中采集血样。通过记录简化口腔卫生指数（OHI-S），出血指数（BI），探查口袋深度（PPD）和临床依从水平（CAL）评估每位患者的牙周状况。使用高灵敏度酶联免疫吸附测定（ELISA）测量血清CRP水平，并使用定量免疫比浊法测定血浆纤维蛋白原水平。数据描述采用均值和标准差的形式进行，数据分析采用单因素方差分析（ANOVA）和学生t检验进行，以检验各组之间的统计学差异。结果：血清CRP和血浆纤维蛋白原的水平与健康对照相比，慢性和侵袭性牙周炎患者的血脂升高（p <0.001）。与CRP和纤维蛋白原以及研究组相比，发现OHI-S，BI，PPD和CAL等临床参数水平之间存在正相关。结论：本研究的发现表明血清作为炎性疾病的诊断标志物，表明CRP和纤维蛋白原的水平可能是评估牙周炎与心血管疾病之间关系的重要生物标志物。

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