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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Serum Creatine Kinase Activity among Hypertensive Patients and its Role as a Predictor for Failure of Antihypertensive Treatment
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Serum Creatine Kinase Activity among Hypertensive Patients and its Role as a Predictor for Failure of Antihypertensive Treatment

机译：高血压患者的血清肌酸激酶活性及其作为抗高血压治疗失败的预测因子

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Creatine Kinase (CK), a key enzyme of cellular energy metabolism helps the cells to function under high demands by involving in contractile processes and active trans-membrane transport by readily providing Adenosine-5?-triphosphate (ATP). Higher CK activity increases cardiovascular trophic responses and development of arterial hypertension. Hence, high CK activity may increase hypertension risk and may also be a cause behind the hypertensive treatment failure.Aim: In the present study, serum CK levels are compared between hypertensive and normotensive study subjects and association of serum CK in hypertensive treatment failure cases.Materials and Methods: A total of 75 known hypertensive patients who were under antihypertensive treatment for =3 months were taken as cases. Further grouping of the patients was done based upon the response to antihypertensive treatment into treatment control (n=40) and without treatment control (n=35) groups. Forty individuals age and sex matched normotensive control were taken. Serum Creatine Kinase, BMI, Systolic Blood Pressure, Diastolic Blood Pressure, was measured in the study group. Kruskal Wallis test was done to compare the parameters in all the three study groups. Correlation of serum CK with other parameters was done. Cut-Off value for serum CK was calculated in hypertensive cases.Results: CK was found to be higher in hypertensive cases with treatment control (99.55±31.34) U/L compared to normotensives (72.66±25.42) U/L. Significantly higher CK level was found in hypertensive treatment failures (313.92±133.12) U/L compared to treatment control cases. Statistically significant correlation was found between serum CK with SBP and DBP in hypertensive treatment failure cases. A cut-off value of 168.5 U/L was found out in hypertensive patients.Conclusion: Serum CK was found to be associated with severity of blood pressure and failure of antihypertensive therapy.
机译：肌酸激酶（CK）是细胞能量代谢的关键酶，通过迅速提供腺苷5α-三磷酸（ATP）参与收缩过程和主动跨膜转运，从而帮助细胞在高需求下发挥功能。较高的CK活性会增加心血管的营养反应和动脉高血压的发展。因此，较高的CK活性可能增加高血压的风险，也可能是高血压治疗失败的原因。目的：在本研究中，比较了高血压和正常血压受试者的血清CK水平以及高血压治疗中血清CK的相关性材料和方法：总共75名接受了3个月的降压治疗的已知高血压患者为例。根据对降压治疗的反应将患者进一步分为治疗对照组（n = 40）和无治疗对照组（n = 35）。采取四十个年龄和性别相匹配的血压控制。在研究组中测量了血清肌酸激酶，BMI，收缩压，舒张压。进行了Kruskal Wallis测试以比较所有三个研究组中的参数。血清CK与其他参数相关。计算高血压患者血清CK的临界值。结果：与正常血压（72.66±25.42）U / L相比，在接受治疗控制（99.55±31.34）U / L的高血压患者中CK更高。与治疗对照组相比，在高血压治疗失败的患者中，CK水平明显升高（313.92±133.12）。在高血压治疗失败的病例中，血清CK与SBP和DBP之间存在统计学意义的相关性。高血压患者的临界值为168.5 U / L。结论：血清CK与血压的严重程度和抗高血压治疗的失败有关。

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