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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Opioid Sparing Effect of Anaesthesia on Postoperative Inflammatory Cytokine Response in Oral Cancer Surgery
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Opioid Sparing Effect of Anaesthesia on Postoperative Inflammatory Cytokine Response in Oral Cancer Surgery

机译：阿片类药物在口腔癌手术中对术后炎性细胞因子反应的保护作用

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Dexmedetomidine is a potent and highly selective alpha-2 adrenoreceptor agonist with the unique sedative, analgesic, perioperative sympatholytic, anaesthetic-sparing and haemodynamic-stabilizing properties. Fentanyl is a potent, synthetic opioid pain medication with a rapid onset and short duration of action.Aim: To examine the effects of fentanyl and dexmedetomidine with paracetamol administered by intravenous route on the postoperative Interleukin (IL-6) and C-reactive protein (CRP) response in oral cancer surgery.Materials and Methods: This prospective comparative study included 60 patient of American Society of Anaesthesiologists (ASA) grade I or II, aged 18 to 70 years. 60 patients were divided into two groups: Group A- Paracetamol (10 mg/kg) with fentanyl (2 μg/kg), maintenance with fentanyl (3 μg/kg); and Group B- Paracetamol (10 mg/kg) with dexmedetomidine (0.5 μg/kg), maintenance with dexmedetomidine (0.4 μg/kg). Blood samples were collected before induction at the end of surgery and 24 hours after surgery for serum level of CRP and IL-6.Results: The demographic profiles such as age, weight, duration of surgery, ASA grade and tumour stage were similar in both groups. CRP and IL-6 level were significantly lower in groups postoperatively at 24 hours as compared to preoperatively and immediate postoperatively. The Visual Analogue Scale (VAS) score and rescue analgesic for 24 hour were lower in group B than group A.Conclusion: Dexmedetomidine is an effective drug which reduces requirement of opioid and potentially increases the analgesia. Adverse effects were not significantly different between the groups.
机译：右美托咪定是一种强效且高度选择性的α-2肾上腺素受体激动剂，具有独特的镇静，镇痛，围手术期交感神经，麻醉剂和血流动力学稳定特性。芬太尼是一种有效的，合成的阿片类镇痛药，起效快且作用时间短。目的：研究芬太尼和右美托咪定联合扑热息痛静脉内给药对术后白介素（IL-6）和C-口腔癌手术中的反应蛋白（CRP）反应。材料与方法：这项前瞻性比较研究包括60例年龄在18至70岁的美国麻醉医师学会（ASA）I级或II级患者。 60例患者分为两组：A组-扑热息痛（10 mg / kg）联合芬太尼（2μg/ kg），芬太尼（3μg/ kg）维持; B组-扑热息痛（10 mg / kg），右美托咪定（0.5μg/ kg），右美托咪定（0.4μg/ kg）维持。在手术结束前和手术后24小时采集血样，以检测CRP和IL-6的血清水平。结果：年龄，体重，手术时间，ASA分级和肿瘤分期等人口统计学资料为：两组相似。与术前和术后即刻相比，术后24小时各组的CRP和IL-6水平显着降低。 B组的视觉模拟量表（VAS）评分和24小时急救镇痛效果均低于A组。结论：右美托咪定是一种有效的药物，可降低阿片类药物的需求并可能增加镇痛作用。两组之间的不良反应无明显差异。

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