...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Inhaled Nitric Oxide in Hypoxic Respiratory Failure in Preterms: Audit of Ten Years of Practice
【24h】

Inhaled Nitric Oxide in Hypoxic Respiratory Failure in Preterms: Audit of Ten Years of Practice

机译：早产儿吸入性一氧化氮在低氧性呼吸衰竭中的作用：十年实践的审计

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: We set out to ascertain the patient profile and practice pattern regarding use of inhaled Nitric Oxide (iNO) in preterm population with oxygenation failure in last ten years. Furthermore, we aim to identify characteristics of patients who respond to iNO.Study Design and Setting: Retrospective chart review in a tertiary teaching referral hospital.Subjects and Intervention: All preterm babies less than 34 weeks gestation with oxygenation failure who were treated with iNO were assessed for inclusion. Response to iNO therapy was defined as decline in oxygenation index by 50% 4 hours after start of iNO. Results: iNO was administered to 26 preterm babies during the study period. Of these, 23 (88.5%) met the inclusion criteria. Total of 13 (56%) infants survived. The iNO responders had a higher gestation age (29 weeks Vs 26.5 weeks), birth weight (1279g Vs 999g), lower initial oxygenation index (38.7 Vs 58), earlier initiation of therapy (20 hours Vs 41.4 hours) and less mortality (25% Vs 86%) when compared to non-responders.Conclusions: Although the infants were at a higher end of spectrum for severity of respiratory illness, nitric administration was successful in improving oxygenation. Characteristics of responders might help in better patient selection and optimize timing of intervention, in case use of Nitric Oxide therapy is being considered.
机译：目的：我们开始确定近十年来有氧合衰竭的早产儿使用吸入一氧化氮（iNO）的患者概况和实践模式。此外，我们的目的是确定对iNO有反应的患者的特征。研究设计和设置：三级转诊医院的回顾性图表回顾研究对象和干预措施：所有经iNO治疗的妊娠少于34周的患有氧合衰竭的早产儿均为评估是否包括在内。对iNO疗法的反应定义为iNO开始后4小时氧合指数下降50％。结果：在研究期间，iNO被给予26个早产儿。其中有23个（88.5％）符合纳入标准。共有13名（56％）婴儿存活。 iNO应答者的胎龄更高（29周vs. 26.5周），出生体重（1279g vs.999g），较低的初始氧合指数（38.7 vs. 58），更早开始治疗（20小时vs.41.4小时）和较低的死亡率（25）结论：尽管婴儿呼吸道疾病的严重程度较高，硝酸盐管理仍能成功改善氧合。在考虑使用一氧化氮治疗的情况下，反应者的特征可能有助于更好地选择患者并优化干预时机。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号