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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Appendiceal Carcinoma with Krukenberg?s Tumour Mimicking Primary Ovarian Cancer
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Appendiceal Carcinoma with Krukenberg?s Tumour Mimicking Primary Ovarian Cancer

机译：阑尾癌与克鲁肯伯格的肿瘤模仿原发性卵巢癌

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Appendiceal adenocarcinoma (AACa) is a rare tumour which represents 0.5% of all gastrointestinal malignancies. The prognosis is poor, because it is usually found at an advanced stage, that in turn, is partly due to a low threshold of suspicion and difficulties in diagnosis prior to surgery. It may occasionally demonstrate ovarian metastases that are large and which dominate the clinical and radiological presentations, leading to a misdiagnosis of an ovarian primary malignancy. We are reporting a case of an occult AACa which manifested clinically as a primary ovarian cancer which was at an advanced stage. Staging laparatomy revealed large bilateral ovarian tumours of clinical FIGO Stage III, with presumed appendiceal implants. Histological examination revealed a mucinous adenocarcinoma with a signet ring component, which involved bilateral ovaries and the appendix transmurally. Immunophenotypic analysis revealed a positive expression of CK 20 and CDX 2 and absence of CK 7 staining, which was compatible with appendiceal primary and ovarian metastases. The diagnosis was subsequently revised to AACa with Krukenberg?s metastasis, Stage IV. Although AACas are uncommon, they should be considered in the differential diagnosis of intraabdominal masses and the distinction between ovarian and appendiceal primary malignancies is critical, as the treatment modalities vary.
机译：阑尾腺癌（AACa）是一种罕见的肿瘤，占所有胃肠道恶性肿瘤的0.5％。预后很差，因为通常在晚期才发现，这部分是由于怀疑阈值低和手术前诊断困难。它可能偶尔会显示出较大的卵巢转移灶，并占临床和放射学表现的主导地位，从而导致对卵巢原发性恶性肿瘤的误诊。我们正在报道一例隐匿性AACa，临床上表现为处于晚期的原发性卵巢癌。分期手术显示临床大体上为FIGO III期的双侧卵巢肿瘤，推测为阑尾植入物。组织学检查发现粘液性腺癌带有一个图章环成分，累及双侧卵巢和经壁阑尾。免疫表型分析显示CK 20和CDX 2阳性表达，而CK 7染色不存在，这与阑尾原发性和卵巢转移是相容的。随后诊断被诊断为伴有克鲁肯伯格转移的IV期AACa。尽管AACas并不常见，但在腹腔内肿块的鉴别诊断中应考虑使用它们，并且由于治疗方式的不同，区分卵巢和阑尾原发性恶性肿瘤至关重要。

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