Introduction: Fluoxetine is a prototype drug of Selective Serotonin Reuptake Inhibitors. Its active demethylated metabolite has a half life of 7-10 d. Fluoxetine is used to treat depression and is also prescribed in premature ejaculation.Aim: In the present study dose and duration dependent effects of Fluoxetine on histology of seminal vesicle of the albino rats were observed.Materials and Methods: The present study was conducted on 36 adult male albino rats. Fluoxetine was administered intraperitoneally for 2 wk, 4 wk and 12 wk with mild (10mg/kg/day), moderate (20mg/kg/day) and severe doses (40mg/kg/day). Histological slides of Seminal vesicle were prepared and stained with Hematoxylin and Eosin stain.Results: On examination through the light microscope, the proliferation of primary, secondary and tertiary villi, increased crypt/alveoli, increased thickness of lamina propria, decreased epithelial cell height, metaplasia, changes in the amount of luminal eosinophilic secretory material in the form of scanty secretion in lumen of seminal vesicle.Conclusion: Low doses for long duration and high doses for short duration of Fluoxetine produce histological changes in seminal vesicle of albino rats.
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机译：简介：氟西汀是选择性5-羟色胺再摄取抑制剂的原型药物。其活性去甲基代谢产物的半衰期为7-10 d。目的：在本研究中，观察氟西汀对白化病大鼠精囊组织学的剂量和持续时间的影响。材料与方法：本研究在36名患者中进行。成年雄性白化病大鼠。腹腔注射氟西汀2周，4周和12周，轻度（10mg / kg /天），中度（20mg / kg /天）和重度（40mg / kg /天）。结果：通过光学显微镜观察，原发，继发和第三绒毛的增殖，隐窝/肺泡增加，固有层厚度增加，上皮细胞高度降低，结论：长剂量低剂量和短时间高剂量氟西汀可引起白化病大鼠精囊的组织学改变，以精囊内腔少分泌的形式改变腔内嗜酸性粒细胞分泌物质的量。
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