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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prevalence of Community-Acquired Methicillin-Resistant Staphylococcus aureus Nasal Colonization Among Children
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Prevalence of Community-Acquired Methicillin-Resistant Staphylococcus aureus Nasal Colonization Among Children

机译：儿童社区获得性耐甲氧西林金黄色葡萄球菌鼻定植的普遍性

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Background: Invasive infections from community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly being encountered in healthy children. Nasal colonization of MRSA is associated with increased risk for acquiring invasive disease. The objective of this study was to determine prevalence and risk factors for CA-MRSA nasal colonization among a healthy paediatric population and to determine antibiotic susceptibilities of S. aureus isolates.Materials and Methods: Using a cross-sectional study design, children aged 1mnth-17y attending well-child clinic at an academic hospital and a local public school in Mangalore, India were screened for S. aureus colonization via nasal swabs. A questionnaire was administered and data on risk factors for nasal colonization was collected. Samples were obtained from the anterior nares and cultured quantitatively. S. aureus isolates were confirmed by growth on selective media and coagulase testing. Disk diffusion antibiotic susceptibility tests were performed according to Clinical and Laboratory Standard Institute guidelines.Results: Of the 500 children included in the study, S. aureus was isolated from the anterior nares in 126 (25%) children; four (3%) isolates were classified as CA-MRSA. Factors associated with S. aureus nasal colonization were children <6 y old (p=0.030) and members of joint families (p=0.044). Resistance to many classes of antibiotics were noted among S. aureus isolates including trimethoprim-sulfamethoxazole (39%), ciprofloxacin (16%), erythromycin (19%) and clindamycin (5%). Inducible clindamycin resistance (positive D test) was detected in 11 of the erythromycin-resistant strains not already classified as resistant to clindamycin. No resistance to vancomycin was observed.Conclusion: Children in India have a high rate of nasal colonization of S. aureus. Nasal colonization of community-associated methicillin-resistant S. aureus exists but is still low among healthy children. The high rate of resistance to many classes of antibiotics among S. aureus strains is of great concern warranting continued surveillance and antimicrobial stewardship.
机译：背景：在健康儿童中，越来越多的社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）侵袭性感染。 MRSA的鼻部定植与增加浸润性疾病的风险有关。这项研究的目的是确定健康儿童人群中CA-MRSA鼻定植的患病率和危险因素，并确定金黄色葡萄球菌分离株的抗生素敏感性。在印度芒格洛尔一家学术医院和当地一所公立学校的儿童诊所就诊的17岁儿童中，通过鼻拭子筛查了金黄色葡萄球菌定植。进行了问卷调查，并收集了有关鼻定植危险因素的数据。从前鼻孔获得样品并进行定量培养。通过在选择性培养基上生长和凝固酶测试确认了金黄色葡萄球菌分离株。结果：在研究中包括的500名儿童中，有126名（25％）的儿童从前鼻孔分离出金黄色葡萄球菌。四个（3％）分离株被分类为CA-MRSA。与金黄色葡萄球菌鼻腔定植有关的因素是<6岁的儿童（p = 0.030）和共同家庭成员（p = 0.044）。在金黄色葡萄球菌分离株中发现了对多种抗生素的抗药性，其中包括甲氧苄氨嘧啶磺胺甲基异恶唑（39％），环丙沙星（16％），红霉素（19％）和克林霉素（5％）。在11种尚未归类为对克林霉素耐药的红霉素耐药菌株中，检测到可诱导的克林霉素耐药性（阳性D检验）。结论：印度儿童金黄色葡萄球菌鼻腔定植率高。存在与社区相关的耐甲氧西林金黄色葡萄球菌的鼻部定植，但在健康儿童中仍较低。在金黄色葡萄球菌菌株中对多种抗生素的高耐药率引起了人们的极大关注，需要继续进行监测和进行抗菌管理。

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